Product Name:SERMORELIN
Form:Acetate salt
Purity:95%
Storage:-20oC
Cas No:86168-78-7
Molar Mass:3357.9
Chemical Formula:C149H246N44O42S
Synonyms:SERMORELIN; Sermorelina; Geref; Sermoreline
IUPAC Name:(3S)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
SMILES:CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC3=CC=C(C=C3)O)N
InChIKey:WGWPRVFKDLAUQJ-MITYVQBRSA-N
InChI:InChI=1S/C149H246N44O42S/c1-20-77(13)116(191-122(211)81(17)168-132(221)104(66-113(204)205)178-121(210)79(15)167-123(212)88(152)62-84-39-43-86(198)44-40-84)145(234)185-102(63-83-32-23-22-24-33-83)138(227)193-118(82(18)197)146(235)186-103(65-111(155)202)137(226)189-108(71-196)142(231)182-101(64-85-41-45-87(199)46-42-85)136(225)175-93(38-31-56-165-149(161)162)126(215)174-91(35-26-28-53-151)131(220)190-115(76(11)12)143(232)184-97(58-72(3)4)124(213)166-68-112(203)170-94(47-49-109(153)200)128(217)180-100(61-75(9)10)135(224)188-106(69-194)140(229)169-80(16)120(209)172-92(37-30-55-164-148(159)160)125(214)173-90(34-25-27-52-150)127(216)179-99(60-74(7)8)134(223)181-98(59-73(5)6)133(222)176-95(48-50-110(154)201)129(218)183-105(67-114(206)207)139(228)192-117(78(14)21-2)144(233)177-96(51-57-236-19)130(219)187-107(70-195)141(230)171-89(119(156)208)36-29-54-163-147(157)158/h22-24,32-33,39-46,72-82,88-108,115-118,194-199H,20-21,25-31,34-38,47-71,150-152H2,1-19H3,(H2,153,200)(H2,154,201)(H2,155,202)(H2,156,208)(H,166,213)(H,167,212)(H,168,221)(H,169,229)(H,170,203)(H,171,230)(H,172,209)(H,173,214)(H,174,215)(H,175,225)(H,176,222)(H,177,233)(H,178,210)(H,179,216)(H,180,217)(H,181,223)(H,182,231)(H,183,218)(H,184,232)(H,185,234)(H,186,235)(H,187,219)(H,188,224)(H,189,226)(H,190,220)(H,191,211)(H,192,228)(H,193,227)(H,204,205)(H,206,207)(H4,157,158,163)(H4,159,160,164)(H4,161,162,165)/t77-,78-,79-,80-,81-,82+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,115-,116-,117-,118-/m0/s1
Sequence:YADAIFTNSYRKVLGQLSARKLLQDIMSR
Target:GHD
Application:Sermorelin is a synthetic growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to produce and release endogenous growth hormone (GH). It is primarily used for the treatment of growth hormone deficiency (GHD) in children and adults, promoting growth, metabolism, and muscle development. Unlike direct GH therapy, Sermorelin encourages natural hormonal regulation, reducing the risk of side effects associated with exogenous GH administration. Current research is exploring its potential in age-related GH decline, muscle wasting disorders, and cognitive health. Additionally, its role in anti-aging medicine, neuroprotection, and metabolic syndrome is being studied for broader therapeutic applications.
Current Research:Sermorelin is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to increase endogenous growth hormone (GH) secretion. Unlike direct recombinant GH therapy, Sermorelin mimics natural physiological GH release patterns, offering a safer and more regulated approach to treating growth hormone deficiency (GHD) and age-related GH decline. Recent studies are investigating its expanding therapeutic applications in aging, neurodegeneration, metabolism, and muscle preservation. Growth Hormone Deficiency (GHD) and Endocrine Disorders Sermorelin is widely used in children and adults with growth hormone deficiency to restore normal growth, development, and metabolic function. Pediatric GHD treatment: Studies confirm that Sermorelin effectively promotes linear growth in children with GH deficiency, making it an alternative to recombinant GH therapy. Adult GHD therapy: Research highlights its benefits in improving muscle mass, bone density, and energy levels in GH-deficient adults. Neuroendocrine interactions: Ongoing studies are assessing Sermorelin??s effects on cognitive function and neuroprotection via GH-induced insulin-like growth factor-1 (IGF-1) signaling in the brain. Anti-Aging Medicine and Age-Related GH Decline Sermorelin is increasingly studied for its potential anti-aging effects, as GH levels naturally decline with age, leading to muscle loss, decreased metabolism, and reduced skin elasticity. Muscle maintenance and sarcopenia prevention: Sermorelin may help preserve lean muscle mass and prevent age-related muscle atrophy. Cognitive benefits: GH has been linked to brain plasticity and memory, and studies suggest Sermorelin may support cognitive function and neuroprotection in aging individuals. Metabolic health: Research is evaluating its role in reducing visceral fat, improving insulin sensitivity, and regulating lipid metabolism, which may help in metabolic syndrome and obesity management. Muscle Wasting and Recovery in Chronic Illnesses Sermorelin is being investigated as a potential therapy for muscle-wasting conditions, including cachexia (cancer-related muscle loss), chronic kidney disease (CKD), and HIV-associated wasting. GH-induced muscle repair: Studies suggest that Sermorelin stimulates muscle protein synthesis and reduces muscle degradation, making it beneficial for conditions involving chronic muscle loss. Post-surgical and sports recovery: Research is exploring its applications in enhancing muscle recovery, tissue repair, and reducing injury-related muscle atrophy. Cognitive and Neuroprotective Research Given the role of GH and IGF-1 in brain health, Sermorelin is being investigated for its neuroprotective properties: Alzheimer??s and neurodegenerative diseases: Studies suggest GH stimulation may help reduce amyloid plaque accumulation and improve neuronal function in neurodegenerative conditions. Cognitive performance and mood regulation: Preliminary findings indicate potential benefits in improving memory, focus, and mental clarity, particularly in aging individuals. Emerging Research Areas Beyond its traditional uses, Sermorelin is being explored for: Athletic performance enhancement, due to its role in muscle recovery and endurance. Sleep disorders, as GH is critical for restorative sleep cycles. Bone health and osteoporosis prevention, particularly in postmenopausal women. With continued research, Sermorelin is emerging as a promising alternative to GH therapy, offering safer, more physiologically balanced hormone stimulation with applications in endocrinology, aging, metabolism, and neuroprotection.
Get a Quote
LinkPeptide
