Spike protein (S1/S2) SARS-CoV-2 substrate

Product Name: Spike protein (S1/S2) SARS-CoV-2 substrate

Sequence One Letter Code: QXL®520-TNSPRRARSVAS-K(5-FAM)-NH2

Sequence Three Letter Code: QXL®520-Thr-Asn-Ser-Pro-Arg-Arg-Ala-Arg-Ser-Val-Ala-Ser-Lys(5-FAM)-OH

Molecular Weight: 2278.4

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C Protected from light

Source / Species: SARS-CoV-2

Conjugation: Conjugated

Conjugation Type: Double dyes

Code Nacres: NA.26

Application: SARS-CoV-2 Spike S1/S2 Furin Cleavage Site FRET Substrate is a synthetic peptide designed to model the polybasic furin-like cleavage site at the S1/S2 junction of the spike protein. Cleavage at this site is an important activation step that supports viral entry, membrane fusion, and infectivity. Labeled with QXL®520 and 5-FAM as a FRET pair, the peptide enables sensitive monitoring of protease activity. It is widely used in studies of furin-mediated spike processing, antiviral inhibitor screening, protease kinetics, viral activation mechanisms, and SARS-CoV-2 entry biology.