TAT-327

TAT-327 is a chimeric peptide formed by linking the Eps8-derived peptide 327 to the HIV-1 TAT cell-penetrating sequence. This design enhances cellular uptake and enables selective insertion into cancer cell membranes. TAT-327 exerts antitumor activity by disrupting the interaction between Eps8 and epidermal growth factor receptor, thereby inhibiting downstream oncogenic signaling pathways. This peptide is widely used in cancer biology research to study EGFR-driven tumor mechanisms, protein–protein interaction disruption, peptide-based anticancer strategies, cell-penetrating peptide delivery, and therapeutic targeting of signaling pathways involved in tumor progression.

Product Name: TAT-327

Sequence One Letter Code: RKKRRQRRREFLDCFQKF

Sequence Three Letter Code: H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Phe-Leu-Asp-Cys-Phe-Gln-Lys-Phe-OH

Chemical Formula:C109H181N41O25S

Molecular Weight: 2498.1

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Unconjugated