[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)

Product Name:[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)

CAS No:93965-89-0

Purity:95%

Molar Mass:3476

Chemical Formula:C157H252N44O43S

Storage:Store at -20 degrees Celsius

Sequence:YFDAIFTNSYRKVLGQLSARKLLQDIMSR

Application:

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) is a synthetic analog of human Growth Hormone-Releasing Factor (GRF), modified to enhance stability and potency. It features an acetylated tyrosine at position 1 and a D-phenylalanine substitution at position 2, with an amidated C-terminus. These modifications make the peptide more resistant to enzymatic degradation, prolonging its biological activity. [Ac-Tyr1,D-Phe2]GRF 1-29, amide is used in research to stimulate growth hormone (GH) release, aiding in the study of GH regulation and potential therapeutic applications for growth hormone deficiencies and endocrine disorders.

Current Research:

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) is a synthetic analog of human growth hormone-releasing factor (GRF), specifically modified with an N-terminal acetylated tyrosine and a D-phenylalanine substitution at position 2. These structural modifications confer the peptide with antagonistic properties against vasoactive intestinal peptide (VIP) receptors. In vitro studies have demonstrated that [Ac-Tyr1,D-Phe2]GRF 1-29, amide selectively inhibits VIP- and GRF-stimulated adenylate cyclase activities in rat pancreatic membranes, indicating its potential utility in modulating VIP-mediated physiological processes. This peptide serves as a valuable tool in research focused on elucidating the roles of VIP and GRF in various biological systems, including their involvement in endocrine regulation and potential implications in disease states. For experimental applications, [Ac-Tyr1,D-Phe2]GRF 1-29, amide is typically stored desiccated at -20 degrees Celsius to maintain its stability and bioactivity. In summary, [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) is a potent VIP receptor antagonist, instrumental in advancing the understanding of peptide hormone interactions and their physiological significance.

Reference:

Liu, D. M., Cuevas, J., & Adams, D. J. (2000). VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation. European Journal of Neuroscience, 12(7), 2243-2251.