ACTH (5-10)

Product Name:ACTH (5-10)

Form:TFA salt

Purity:95%

Storage:2-8 degree Celsius

Cas No:4086-29-7

Molar Mass:830.9

Chemical Formula:C39H50N12O9

IUPAC Name:(4S)-4-amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-(carboxymethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(4H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

SMILES:C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)O)NC(=O)[C@H](CC4C=NC=N4)NC(=O)[C@H](CCC(=O)O)N

InChIKey:QKTOUAVYHKEQCE-YJLTWGPUSA-N

InChI:InChI=1S/C39H50N12O9/c40-26(12-13-32(52)53)34(56)49-31(17-24-19-43-21-47-24)38(60)50-29(15-22-7-2-1-3-8-22)37(59)48-28(11-6-14-44-39(41)42)36(58)51-30(35(57)46-20-33(54)55)16-23-18-45-27-10-5-4-9-25(23)27/h1-5,7-10,18-19,21,24,26,28-31,45H,6,11-17,20,40H2,(H,46,57)(H,48,59)(H,49,56)(H,50,60)(H,51,58)(H,52,53)(H,54,55)(H4,41,42,44)/t24,26-,28-,29-,30-,31-/m0/s1

Sequence:Glu-His-Phe-Arg-Trp-Gly

Application:

ACTH (5-10) is a short peptide fragment of adrenocorticotropic hormone (ACTH) that retains part of the biologically active core involved in melanocortin receptor interactions. Although it lacks the full sequence required for adrenal steroidogenesis, ACTH (5-10) has been studied for its effects on neuroendocrine function, cognitive processes, and immune modulation. Research suggests that it may play a role in neurotransmitter regulation, learning, memory, and stress adaptation. Due to its structural properties, ACTH (5-10) is used in studies related to neuroprotection, mood regulation, and inflammation, particularly in models of neurodegenerative diseases, cognitive decline, and immune-related disorders.

Current Research:

Introduction
ACTH is a key regulator of the hypothalamic-pituitary-adrenal (HPA) axis, responsible for stimulating adrenal corticosteroid production. While full-length ACTH (1-39) is required for activating melanocortin 2 receptor (MC2R) in the adrenal cortex, shorter fragments such as ACTH (5-10) exhibit distinct biological effects, particularly in neuromodulation and immune regulation. This pentapeptide fragment has been studied for its role in cognition, neuroprotection, and immune response modulation.

Neurobiological and Cognitive Research
Studies suggest that ACTH (5-10) influences learning, memory, and synaptic plasticity, likely through interactions with melanocortin receptors (MC4R and MC5R) in the brain. Research highlights:

Memory enhancement: ACTH (5-10) has been shown to improve cognitive function in experimental models of age-related memory decline and neurodegeneration.
Neurotransmitter regulation: The peptide may influence dopaminergic, serotonergic, and cholinergic pathways, which are critical for cognition and mood regulation.
Neuroprotection: Some studies suggest that ACTH (5-10) may reduce oxidative stress and inflammation in neurons, making it a potential candidate for research on Alzheimer’s disease and Parkinson’s disease.
Stress and Mood Regulation
Melanocortin peptides, including ACTH fragments, are involved in stress adaptation. ACTH (5-10) has been explored for its effects on behavioral and physiological stress responses, with findings indicating:

Anxiolytic and antidepressant-like properties, potentially by modulating cortisol release and central nervous system activity.
HPA axis regulation, suggesting a role in stress resilience and neuroendocrine balance.
These findings open research opportunities into mood disorders, anxiety, and post-traumatic stress disorder (PTSD).

Immunomodulatory and Anti-Inflammatory Effects
ACTH-derived peptides have been linked to immune regulation via melanocortin receptor interactions on immune cells. Studies indicate that ACTH (5-10) may:

Reduce inflammatory cytokine production (such as IL-6 and TNF-α).
Modulate immune cell function, suggesting applications in autoimmune diseases and chronic inflammation.
Protect against neuroinflammation, potentially benefiting conditions like multiple sclerosis and neurodegenerative disorders.
Potential Therapeutic Applications
Due to its neuromodulatory, stress-regulating, and immune-modulating properties, ACTH (5-10) is being explored for:

Cognitive enhancement therapies for dementia, cognitive decline, and brain injury recovery.
Mood disorder treatments, including depression, anxiety, and PTSD.
Neuroimmune therapies, particularly for neuroinflammation-related diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis.
Conclusion
ACTH (5-10) is a neuroactive peptide fragment with significant implications in cognitive function, stress regulation, and immune modulation. While it does not stimulate adrenal corticosteroid release, it is widely used in research on memory, neurotransmission, and inflammation. Ongoing studies suggest potential therapeutic applications in neuroprotection, psychiatric disorders, and immune-related diseases, making ACTH (5-10) a promising candidate for neurological and immunological research.