Adrenomedullin (11-50), rat

Product Name:Adrenomedullin (11-50), rat

Form:free base

Purity:95%

Storage:2-8 degree Celsius

Cas No:163648-32-6

Molar Mass:4521.2

Chemical Formula:C194H304N58O59S4

IUPAC Name:(3S)-3-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(4R,7S,13S,16S,19R)-19-[[2-[[(2S,3R)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-13-benzyl-16-(3-carbamimidamidopropyl)-7-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]-4-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[2-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-4-oxobutanoic acid

SMILES:CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CC5=CC=C(C=C5)O)C(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC6=CNC=N6)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]7CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N7)[C@@H](C)O)CC8=CC=CC=C8)CCCNC(=N)N)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)N

InChIKey:NUPJXZFLGDYTBJ-UYMRUBGFSA-N

InChI:InChI=1S/C194H304N58O59S4/c1-15-96(5)151(247-173(292)121(58-62-142(203)264)230-176(295)129(80-108-85-210-94-217-108)234-158(277)98(7)218-174(293)125(75-95(3)4)235-164(283)112(39-23-27-65-195)223-169(288)119(56-60-140(201)262)228-171(290)123(64-74-313-14)233-189(308)155(102(11)257)250-182(301)136-93-315-314-92-135(222-146(268)88-216-185(304)153(100(9)255)248-159(278)111(199)90-253)181(300)227-116(43-31-69-211-193(206)207)167(286)236-126(77-104-35-19-17-20-36-104)161(280)215-89-147(269)245-154(101(10)256)188(307)244-136)186(305)241-127(79-107-49-53-110(260)54-50-107)175(294)229-120(57-61-141(202)263)170(289)237-128(78-105-37-21-18-22-38-105)180(299)249-156(103(12)258)190(309)242-133(84-150(274)275)179(298)225-114(41-25-29-67-197)166(285)240-132(83-149(272)273)178(297)224-113(40-24-28-66-196)165(284)239-131(82-148(270)271)162(281)214-86-144(266)220-122(63-73-312-13)163(282)219-99(8)191(310)251-71-33-45-137(251)183(302)231-117(44-32-70-212-194(208)209)168(287)238-130(81-143(204)265)177(296)226-115(42-26-30-68-198)172(291)246-152(97(6)16-2)187(306)243-134(91-254)192(311)252-72-34-46-138(252)184(303)232-118(55-59-139(200)261)160(279)213-87-145(267)221-124(157(205)276)76-106-47-51-109(259)52-48-106/h17-22,35-38,47-54,85,94-103,111-138,151-156,253-260H,15-16,23-34,39-46,55-84,86-93,195-199H2,1-14H3,(H2,200,261)(H2,201,262)(H2,202,263)(H2,203,264)(H2,204,265)(H2,205,276)(H,210,217)(H,213,279)(H,214,281)(H,215,280)(H,216,304)(H,218,293)(H,219,282)(H,220,266)(H,221,267)(H,222,268)(H,223,288)(H,224,297)(H,225,298)(H,226,296)(H,227,300)(H,228,290)(H,229,294)(H,230,295)(H,231,302)(H,232,303)(H,233,308)(H,234,277)(H,235,283)(H,236,286)(H,237,289)(H,238,287)(H,239,284)(H,240,285)(H,241,305)(H,242,309)(H,243,306)(H,244,307)(H,245,269)(H,246,291)(H,247,292)(H,248,278)(H,249,299)(H,250,301)(H,270,271)(H,272,273)(H,274,275)(H4,206,207,211)(H4,208,209,212)/t96-,97-,98-,99-,100+,101+,102+,103+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,151-,152-,153-,154-,155-,156-/m0/s1

Sequence:Ser-Thr-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Met-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Gly-Met-Ala-Pro-Arg-Asn-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2

Application:Adrenomedullin (11-50), rat is a bioactive peptide fragment derived from adrenomedullin (ADM), spanning amino acids 11-50. This fragment retains essential functional regions involved in vasodilation, immune regulation, and metabolic processes. Studies indicate that ADM (11-50) plays a key role in cardiovascular homeostasis, endothelial function, and inflammatory response modulation. It is widely used in hypertension, heart failure, and sepsis research, with potential applications in vascular protection, immune system modulation, and metabolic disease models. Due to its ability to interact with ADM receptors, ADM (11-50) is a significant research tool for peptide-based therapeutics and biomarker discovery.

Current Research:

Introduction
Adrenomedullin (11-50), rat, is a biologically active fragment of rat adrenomedullin (ADM), a peptide hormone that plays a critical role in vascular regulation, immune response, and metabolic balance. The 11-50 sequence retains functional regions responsible for binding to calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), which mediate ADM’s effects. This fragment is extensively studied in preclinical models for cardiovascular, immunological, and metabolic research, particularly in hypertension, heart failure, and inflammation-related conditions.

Cardiovascular and Vasodilatory Research
ADM and its fragments, including ADM (11-50), play a crucial role in blood pressure regulation and vascular function. Studies in rat models suggest that ADM (11-50):

Stimulates nitric oxide (NO) pathways, leading to vasodilation and improved endothelial function.
Regulates vascular permeability, preventing capillary leakage and inflammatory edema.
Protects against ischemic damage, reducing the risk of heart failure and stroke.
Given its vasoprotective properties, ADM (11-50) is a valuable research target for hypertension, ischemia, and endothelial dysfunction studies.

Immunomodulatory and Anti-Inflammatory Effects
ADM is known for its immune-regulating functions, and research on ADM (11-50) in rat models suggests:

Inhibition of pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β), reducing inflammatory responses in sepsis and autoimmune diseases.
Regulation of macrophage and neutrophil activity, impacting infection response and wound healing.
Protection against endothelial inflammation, making it relevant in chronic inflammatory conditions such as atherosclerosis and inflammatory bowel disease.
Due to these properties, ADM (11-50) is a promising candidate for sepsis, inflammatory disease, and immune response research in rat models.

Metabolic and Endocrine Research
ADM is involved in glucose and lipid metabolism, and studies on ADM (11-50) in rats indicate:

Potential regulation of insulin secretion, making it relevant in diabetes and metabolic syndrome research.
Influence on stress hormone signaling, impacting adrenal function and energy homeostasis.
Lipid metabolism modulation, positioning it as a candidate for obesity and cardiovascular risk management research.
These findings highlight ADM (11-50) as a key target for endocrine and metabolic disease therapies.

Potential Research and Therapeutic Applications
Due to its vasodilatory, immune-regulating, and metabolic-stabilizing effects, ADM (11-50), rat, is being explored for:

Cardiovascular disease models, particularly in hypertension and endothelial dysfunction studies.
Sepsis and immune-related inflammatory research, focusing on cytokine dysregulation and infection response.
Metabolic disorder research, including insulin regulation, glucose homeostasis, and lipid metabolism.
Conclusion
Adrenomedullin (11-50), rat, is a bioactive peptide fragment involved in vascular regulation, immune function, and metabolic balance. Its vasodilatory, anti-inflammatory, and metabolic properties make it a valuable research tool in preclinical cardiovascular, immunology, and endocrine studies. Ongoing research continues to explore its therapeutic potential in blood pressure regulation, sepsis management, and metabolic disorders, with promising applications in biomarker discovery and peptide-based drug development.