ALARELIN ACETATE

Product Name:ALARELIN ACETATE

Form:Acetate salt

Purity:95%

Storage:-20^oC

Cas No:79561-22-1

Molar Mass:1287.4

Chemical Formula:C60H86N16O16

IUPAC Name:acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

SMILES:CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6.CC(=O)O.CC(=O)O

InChIKey:DPWSRXJWCYEGIV-PFHUABGLSA-N

InChI:InChI=1S/C56H78N16O12.2C2H4O2/c1-5-60-54(83)45-13-9-21-72(45)55(84)39(12-8-20-61-56(57)58)66-50(79)40(22-30(2)3)67-47(76)31(4)64-49(78)41(23-32-14-16-35(74)17-15-32)68-53(82)44(28-73)71-51(80)42(24-33-26-62-37-11-7-6-10-36(33)37)69-52(81)43(25-34-27-59-29-63-34)70-48(77)38-18-19-46(75)65-38;2*1-2(3)4/h6-7,10-11,14-17,26-27,29-31,38-45,62,73-74H,5,8-9,12-13,18-25,28H2,1-4H3,(H,59,63)(H,60,83)(H,64,78)(H,65,75)(H,66,79)(H,67,76)(H,68,82)(H,69,81)(H,70,77)(H,71,80)(H4,57,58,61);2*1H3,(H,3,4)/t31-,38+,39+,40+,41+,42+,43+,44+,45+;;/m1../s1

Sequence:XHWSYALRP

Application:Alarelin Acetate is a synthetic gonadotropin-releasing hormone (GnRH) agonist that stimulates the hypothalamic-pituitary-gonadal (HPG) axis, leading to the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This results in increased estrogen or testosterone production, making it useful for ovulation induction and reproductive studies. With prolonged use, it induces desensitization of GnRH receptors, leading to gonadal suppression, which is beneficial for treating endometriosis, uterine fibroids, and hormone-sensitive cancers. Current research explores its applications in fertility treatments, endocrine disorders, and neuroendocrine regulation, positioning it as a promising tool in reproductive medicine and hormone therapy.

Current Research:Alarelin Acetate is a synthetic gonadotropin-releasing hormone (GnRH) agonist that plays a critical role in reproductive health and hormonal regulation. By acting on GnRH receptors in the anterior pituitary, it stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to increased gonadal steroidogenesis. Prolonged use results in desensitization of GnRH receptors, ultimately suppressing gonadotropin secretion, which has applications in fertility control, hormone-related disorders, and cancer therapy. Reproductive Health and Fertility Research Alarelin is widely studied for its role in ovulation induction and fertility regulation: Ovulation induction in assisted reproductive technologies (ART): It is used to stimulate LH and FSH secretion, enhancing follicle development and ovulation. Polycystic ovary syndrome (PCOS) treatment: Research explores its ability to modulate LH/FSH balance, potentially improving ovulatory cycles in PCOS patients. Controlled ovarian stimulation: In some ART protocols, Alarelin is used to trigger ovulation, offering an alternative to hCG for final oocyte maturation. Hormone-Dependent Disease Management Alarelin??s ability to downregulate gonadal hormone production makes it a potential treatment for hormone-sensitive conditions: Endometriosis: By suppressing estrogen production, Alarelin can reduce endometrial tissue growth and associated pain. Uterine fibroids: Research indicates that Alarelin may shrink fibroid size by lowering estrogen levels. Prostate and breast cancer treatment: Like other GnRH agonists, it is being explored for reducing testosterone and estrogen levels to slow tumor progression in hormone-sensitive cancers. Neuroendocrine and Metabolic Research Regulation of the HPG axis: Studies use Alarelin to investigate the effects of GnRH signaling on endocrine function and puberty onset. Potential role in metabolic syndrome: Research is exploring whether GnRH agonists influence insulin sensitivity, lipid metabolism, and weight regulation. Emerging Research Areas Bone health and osteoporosis: Since long-term GnRH agonist use affects bone mineral density, research focuses on strategies to mitigate bone loss. Neurodegenerative disease studies: Some studies suggest GnRH modulation may have neuroprotective effects, particularly in Alzheimer??s and Parkinson??s disease research. Reversible contraception: Investigations explore whether Alarelin can provide a temporary, reversible method of fertility suppression. With expanding research, Alarelin Acetate remains a valuable tool in reproductive medicine, hormone therapy, and metabolic health research.

Reference:Zhang, Z., Li, R., Liu, S., Yin, L., Xu, T., Fawcett, J. P., & Gu, J. (2019). Liquid chromatography tandem mass spectrometry with triple stage fragmentation for highly selective analysis and pharmacokinetics of alarelin in rat plasma. Journal of Separation Science, 42(18), 3033-3040.