AR-M 1896

Product Name:AR-M 1896

CAS No:367518-31-8

Purity:95%

Molar Mass:1136.31

Chemical Formula:C54H81N13O14

Storage:Store at -20 degrees Celsius

Sequence:WTLNSAGYLL

Target:GAL2

Application:

AR-M 1896 is a selective antagonist for the galanin receptor 2 (GAL2). It is used in research to block the activity of the galanin neuropeptide at the GAL2 receptor, which is involved in various physiological processes such as mood regulation, pain perception, feeding behavior, and neuroprotection. AR-M 1896 helps researchers explore the specific functions of GAL2 in both the central and peripheral nervous systems, shedding light on its potential therapeutic role in neuropsychiatric disorders, chronic pain management, and metabolic diseases. Its use aids in distinguishing the effects mediated by GAL2 from those of other galanin receptors.

Current Research:

AR-M 1896, with the CAS number 367518-31-8, is a synthetic peptide that functions as a selective agonist for the galanin receptor subtype 2 (GalR2). It exhibits high affinity for GalR2, with an IC₅₀ of 1.76 nM, while demonstrating significantly lower affinity for GalR1, with an IC₅₀ of 879 nM. This selectivity makes AR-M 1896 a valuable tool for investigating the specific roles of GalR2 in various physiological and pathological processes.

Biological Activity

AR-M 1896 has been instrumental in elucidating the functions of GalR2, particularly in the modulation of pain and seizure activity:

Pain Modulation: Studies have demonstrated that AR-M 1896 can mimic the pronociceptive effects of galanin when administered intrathecally in rodent models, indicating its potential utility in pain research.

Seizure Activity: Research involving the administration of AR-M 1896 has shown that it can prevent full seizures and post-kindling increases in hippocampal excitability, suggesting a potential antiepileptogenic effect.

Research Applications

Due to its specificity, AR-M 1896 serves as a critical tool in:

Dissecting the distinct functions of GalR2 receptors in the central and peripheral nervous systems.

Investigating the involvement of GalR2 in conditions such as epilepsy, pain, and anxiety disorders.

Developing potential therapeutic strategies targeting GalR2-mediated pathways.

Reference:

Mansouri, S., Barde, S., Ortsäter, H., Eweida, M., Darsalia, V., Langel, Ü., … & Patrone, C. (2013). GalR3 activation promotes adult neural stem cell survival in response to a diabetic milieu. Journal of neurochemistry, 127(2), 209-220.