[Arg(Me2a)8]-Histone H3(1-21)-K(Biotin)-NH2

Product Name: [Arg(Me2a)8]-Histone H3(1-21)-K(Biotin)-NH2

Sequence One Letter Code: ARTKQTA-R(Me2a)-KSTGGKAPRKQLA-K(Biotin)-NH2

Sequence Three Letter Code: H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg(Me2a)-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Lys(Biotin)-NH2

Molecular Weight: 2636.3

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: [Arg(Me2a)8]-Histone H3 (1–21)-K(Biotin) is a synthetic histone H3 N-terminal peptide asymmetrically dimethylated at arginine 8 and biotinylated at a C-terminal lysine. In asymmetric dimethylation, both methyl groups are added to the same nitrogen atom of the arginine guanidinium group. H3R8 asymmetric dimethylation is linked to transcriptional activation, chromatin remodeling, and arginine methylation-dependent signaling. The biotin tag enables affinity capture, immobilization, pull-down assays, and binding studies. This peptide is commonly used to investigate PRMT enzyme specificity, histone reader interactions, epigenetic regulation, and transcriptional control.