B-type Natriuretic Peptide, BNP-45, mouse

Mouse BNP-45 is the biologically active C-terminal fragment of the B-type natriuretic peptide prohormone and retains residues required for natriuretic peptide activity. BNP regulates cardiovascular function by promoting vasodilation, natriuresis, cardiac load reduction, and modulation of cardiac remodeling. Comparative studies suggest conserved proteolytic processing motifs between rodent and higher mammalian BNP precursors, consistent with cleavage by furin-like proteases. Mouse BNP-45 is commonly used in cardiovascular and endocrine research to study BNP signaling, peptide processing, blood pressure regulation, cardiac function, renal sodium handling, and species-specific natriuretic peptide biology.

Product Name: B-type Natriuretic Peptide, BNP-45, mouse

Sequence One Letter Code: SQGSTLRVQQRPQNSKVTHISSCFGHKIDRIGSVSRLGCNALKLL (Disulfide bridge:23-39)

Sequence Three Letter Code: H-Ser-Gln-Gly-Ser-Thr-Leu-Arg-Val-Gln-Gln-Arg-Pro-Gln-Asn-Ser-Lys-Val-Thr-His-Ile-Ser-Ser-Cys-Phe-Gly-His-Lys-Ile-Asp-Arg-Ile-Gly-Ser-Val-Ser-Arg-Leu-Gly-Cys-Asn-Ala-Leu-Lys-Leu-Leu-OH (Disulfide bridge:23-39)

Purity: ≥ 95%

Chemical Formula:C209H354N70O63S2

Molecular Weight: 4919.9

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: mouse

Conjugation: Unconjugated

Code Nacres: NA.26

Cas No: 1816939-52-2

SMILES: CC[C@H](C)[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)CC(=O)O)[C@@H](C)CC)CCCCN)CC2=CNC=N2)CC3=CC=CC=C3)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)CC(C)C)CCCNC(=N)N)CO)C(C)C)CO

IUPAC: (2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(4R,10S,13S,16S,19S,22S,28S,31S,34S,37S,40S,43S,49S,52R)-52-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-40-(4-aminobutyl)-49-benzyl-28,37-bis[(2S)-butan-2-yl]-13,31-bis(3-carbamimidamidopropyl)-34-(carboxymethyl)-16,22-bis(hydroxymethyl)-43-(1H-imidazol-4-ylmethyl)-10-(2-methylpropyl)-6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-hexadecaoxo-19-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecazacyclotripentacontane-4-carbonyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoic acid

INCHIKEY: HORSYDXFUMMCFJ-MMBYWGHXSA-N

INCHI:

InChI=1S/C209H354N70O63S2/c1-26-105(20)160-196(332)237-85-154(297)242-137(87-281)191(327)273-158(103(16)17)198(334)268-141(91-285)188(324)251-118(48-38-64-230-206(220)221)171(307)257-126(69-97(4)5)168(304)235-84-155(298)244-143(193(329)261-133(77-150(218)293)179(315)240-108(23)165(301)256-127(70-98(6)7)180(316)246-115(45-32-35-61-210)170(306)258-128(71-99(8)9)182(318)265-136(205(341)342)73-101(12)13)93-343-344-94-144(194(330)259-130(74-111-43-30-29-31-44-111)169(305)236-82-152(295)241-131(75-112-80-228-95-238-112)183(319)247-117(47-34-37-63-212)177(313)275-161(106(21)27-2)200(336)264-135(79-156(299)300)185(321)249-120(178(314)274-160)50-40-66-232-208(224)225)270-190(326)140(90-284)267-189(325)142(92-286)269-201(337)162(107(22)28-3)276-186(322)132(76-113-81-229-96-239-113)263-203(339)164(110(25)288)278-199(335)159(104(18)19)272-175(311)116(46-33-36-62-211)250-187(323)139(89-283)266-184(320)134(78-151(219)294)260-174(310)123(55-59-148(216)291)253-195(331)145-52-42-68-279(145)204(340)125(51-41-67-233-209(226)227)255-173(309)122(54-58-147(215)290)252-172(308)124(56-60-149(217)292)254-197(333)157(102(14)15)271-176(312)119(49-39-65-231-207(222)223)248-181(317)129(72-100(10)11)262-202(338)163(109(24)287)277-192(328)138(88-282)243-153(296)83-234-167(303)121(53-57-146(214)289)245-166(302)114(213)86-280/h29-31,43-44,80-81,95-110,114-145,157-164,280-288H,26-28,32-42,45-79,82-94,210-213H2,1-25H3,(H2,214,289)(H2,215,290)(H2,216,291)(H2,217,292)(H2,218,293)(H2,219,294)(H,228,238)(H,229,239)(H,234,303)(H,235,304)(H,236,305)(H,237,332)(H,240,315)(H,241,295)(H,242,297)(H,243,296)(H,244,298)(H,245,302)(H,246,316)(H,247,319)(H,248,317)(H,249,321)(H,250,323)(H,251,324)(H,252,308)(H,253,331)(H,254,333)(H,255,309)(H,256,301)(H,257,307)(H,258,306)(H,259,330)(H,260,310)(H,261,329)(H,262,338)(H,263,339)(H,264,336)(H,265,318)(H,266,320)(H,267,325)(H,268,334)(H,269,337)(H,270,326)(H,271,312)(H,272,311)(H,273,327)(H,274,314)(H,275,313)(H,276,322)(H,277,328)(H,278,335)(H,299,300)(H,341,342)(H4,220,221,230)(H4,222,223,231)(H4,224,225,232)(H4,226,227,233)/t105-,106-,107-,108-,109+,110+,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,157-,158-,159-,160-,161-,162-,163-,164-/m0/s1