Beta-Amyloid (1-39) Peptide

Product Name: Beta-Amyloid (1-39) Peptide

Sequence One Letter Code: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGV

Sequence Three Letter Code: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-OH

Cas No: 115427-62-8

Chemical Formula:C189H286N52O57S

Molecular Weight: 4231

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC6=CNC=N6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)N

IUPAC: (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[[(1S)-1-carboxy-2-methylpropyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]propanoyl]amino]-5-oxopentanoic acid

INCHIKEY: ZIZSPTDSSIONIO-FKGJHEENSA-N

INCHI:

InChI=1S/C189H286N52O57S/c1-23-99(17)154(184(293)206-85-140(250)213-121(65-92(3)4)170(279)223-120(60-64-299-22)168(277)236-149(94(7)8)182(291)204-81-137(247)201-82-142(252)235-153(98(15)16)188(297)298)241-187(296)155(100(18)24-2)240-158(267)101(19)210-138(248)83-202-160(269)113(45-34-36-61-190)218-177(286)130(75-136(194)246)229-181(290)134(88-243)215-141(251)86-205-183(292)150(95(9)10)237-180(289)132(77-148(263)264)230-166(275)118(54-58-144(255)256)217-157(266)103(21)212-169(278)124(67-104-39-28-25-29-40-104)226-173(282)126(69-106-43-32-27-33-44-106)232-185(294)152(97(13)14)239-179(288)122(66-93(5)6)224-162(271)114(46-35-37-62-191)219-164(273)116(52-56-135(193)245)221-174(283)127(71-108-78-197-89-207-108)228-176(285)129(73-110-80-199-91-209-110)233-186(295)151(96(11)12)238-167(276)119(55-59-145(257)258)222-171(280)123(70-107-48-50-111(244)51-49-107)214-139(249)84-203-161(270)133(87-242)234-178(287)131(76-147(261)262)231-175(284)128(72-109-79-198-90-208-109)227-163(272)115(47-38-63-200-189(195)196)220-172(281)125(68-105-41-30-26-31-42-105)225-165(274)117(53-57-143(253)254)216-156(265)102(20)211-159(268)112(192)74-146(259)260/h25-33,39-44,48-51,78-80,89-103,112-134,149-155,242-244H,23-24,34-38,45-47,52-77,81-88,190-192H2,1-22H3,(H2,193,245)(H2,194,246)(H,197,207)(H,198,208)(H,199,209)(H,201,247)(H,202,269)(H,203,270)(H,204,291)(H,205,292)(H,206,293)(H,210,248)(H,211,268)(H,212,278)(H,213,250)(H,214,249)(H,215,251)(H,216,265)(H,217,266)(H,218,286)(H,219,273)(H,220,281)(H,221,283)(H,222,280)(H,223,279)(H,224,271)(H,225,274)(H,226,282)(H,227,272)(H,228,285)(H,229,290)(H,230,275)(H,231,284)(H,232,294)(H,233,295)(H,234,287)(H,235,252)(H,236,277)(H,237,289)(H,238,276)(H,239,288)(H,240,267)(H,241,296)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,297,298)(H4,195,196,200)/t99-,100-,101-,102-,103-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,149-,150-,151-,152-,153-,154-,155-/m0/s1

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Beta-Amyloid (1–39) is a naturally occurring amyloid peptide variant with a shortened C-terminal region compared with major amyloid species such as Aβ(1–40) and Aβ(1–42). The C-terminal length of beta-amyloid peptides strongly influences aggregation kinetics, fibril nucleation, and peptide stability. Aβ(1–39) is generally more kinetically soluble than longer amyloid peptides, but its aggregation may be promoted by seeding from extended C-terminal variants such as Aβ(1–42). This peptide is widely used to study amyloid nucleation, seeding mechanisms, C-terminal truncation, and beta-amyloid aggregation behavior.