Bid BH3-R8

Product Name: Bid BH3-R8

Sequence One Letter Code: RRRRRRRRGEDIIRNIARHLAQVGDSMDR

Sequence Three Letter Code: H-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-Gly-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg

Chemical Formula:C145H260N66O41S1

Molecular Weight: 3616.2

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Bid BH3-R8 is a cell-permeable pro-apoptotic peptide derived from the BH3 domain of Bid, a BH3-only member of the BCL-2 protein family. The BH3 domain antagonizes anti-apoptotic proteins such as Bcl-2 and promotes mitochondrial apoptosis. Fusion with a poly-D-arginine sequence enables efficient cellular uptake, making this peptide suitable for cell-based studies. Bid BH3-R8 has demonstrated cytotoxic activity in leukemia cell lines expressing Bcl-2. It is widely used in apoptosis research, cancer biology, mitochondrial signaling studies, and evaluation of BCL-2 antagonists with potential relevance to cancer therapy.