Cardiac Ryanodine Receptor RYR2 (2460-2495)

Product Name: Cardiac Ryanodine Receptor RYR2 (2460-2495)

Sequence One Letter Code: GFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLP

Sequence Three Letter Code: H-Gly-Phe-Cys-Pro-Asp-His-Lys-Ala-Ala-Met-Val-Leu-Phe-Leu-Asp-Arg-Val-Tyr-Gly-Ile-Glu-Val-Gln-Asp-Phe-Leu-Leu-His-Leu-Leu-Glu-Val-Gly-Phe-Leu-Pro-OH

Chemical Formula:C194H293N45O49S2

Molecular Weight: 4104.1

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human, rat, rabbit, mouse

Conjugation: Unconjugated

Code Nacres: NA.26

Application: RyR2 (2460–2495) is a synthetic peptide corresponding to amino acid residues 2460–2495 of cardiac ryanodine receptor type 2, a major calcium release channel in cardiac muscle cells. RyR2 mediates calcium flux from the sarcoplasmic reticulum and initiates excitation–contraction coupling in cardiomyocytes. Dysregulation or mutation of RyR2 is strongly associated with cardiac arrhythmias, including ventricular tachycardia and sudden cardiac death. This peptide is suitable for studies of RyR2 structure–function relationships, antibody generation, intracellular calcium signaling, cardiovascular disease mechanisms, cardiac physiology, and calcium channel regulation.