[Cit17]-Histone H3 (1-21)-GGK(Biotin)

Product Name: [Cit17]-Histone H3 (1-21)-GGK(Biotin)

Sequence One Letter Code: ARTKQTARKSTGGKAP-Cit-KQLA-GGK(Biotin)

Sequence Three Letter Code: H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Cit-Lys-Gln-Leu-Ala-Gly-Gly-Lys(Biotin)-OH

Molecular Weight: 2724.3

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: [Cit17]-Histone H3 (1–21)-GGK(Biotin) is a synthetic histone H3 peptide containing citrullination, or deimination, of arginine 17 to citrulline. This post-translational modification is catalyzed by peptidyl arginine deiminase 4 and can block CARM1-mediated arginine methylation, thereby suppressing transcriptional activation. The peptide includes a C-terminal GGK linker and biotinylated lysine, enabling streptavidin-based pull-down, binding, and interaction assays. [Cit17]-Histone H3 is widely used to study histone modification crosstalk, citrullination-dependent chromatin signaling, transcriptional repression mechanisms, PADI4 activity, and regulatory interactions between methylation and deimination marks.