Cyclo (-GRGDSP)

Product Name: Cyclo (-GRGDSP)

Sequence One Letter Code: GRGDSP, N to C cyclized

Sequence Three Letter Code: Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro)

Chemical Formula:C22H35N9O9

Molecular Weight: 569.6

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: mouse, rat, human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Cyclo(-GRGDSP) is a cyclic RGD-containing peptide that interacts with integrin receptors involved in cell adhesion, matrix recognition, and vascular regulation. Cyclization enhances conformational rigidity and biological activity compared with the linear GRGDSP sequence. This peptide exhibits potent vasodilatory effects and has been shown to influence vascular tone in isolated arterioles. Cyclo(-GRGDSP) is commonly used in studies of integrin-mediated signaling, vascular physiology, endothelial function, cell–matrix interactions, angiogenesis, and integrin-targeted therapeutic strategies. It provides a useful cyclic RGD model for examining adhesion-dependent cellular and vascular responses.