Fibrinolysis Inhibiting Factor

Fibrin Alpha-Chain N-Terminal Mimic Peptide is designed to mimic the N-terminus of the fibrin alpha-chain and bind tightly to the fibrin polymerization pocket. By forming peptide–fibrinogen complexes, it inhibits fibrin assembly, alters clot stability, increases resistance to plasmin-mediated degradation, and suppresses polymerization reactions. This peptide also prevents factor XIIIa-mediated crosslinking, supporting mechanistic studies of clot maturation and breakdown. It is widely used in coagulation research, fibrin structural studies, fibrinolysis investigations, thrombosis research, and assays exploring the molecular regulation of clot formation, stabilization, and degradation.

Product Name: Fibrinolysis Inhibiting Factor

Sequence One Letter Code: GPRP

Sequence Three Letter Code: H-Gly-Pro-Arg-Pro-OH

Cas No: 67869-62-9

Chemical Formula:C18H31N7O5

Molecular Weight: 425.5

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Unconjugated

 Code Nacres: NA.26

SMILES: C1C[C@H](N(C1)C(=O)CN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)O

IUPAC: (2S)-1-[(2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxylic acid

INCHIKEY: WXPZDDCNKXMOMC-AVGNSLFASA-N

INCHI:

InChI=1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1