gp91 ds-tat, NADPH oxidase inhibitor

Product Name: gp91 ds-tat, NADPH oxidase inhibitor

Sequence One Letter Code: YGRKKRRQRRRCSTRIRRQL-NH2

Sequence Three Letter Code: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Ser-Thr-Arg-Ile-Arg-Arg-Gln-Leu-NH2

Chemical Formula:C109H202N52O25S1

Molecular Weight: 2673.3

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: HIV

Conjugation: Unconjugated

Code Nacres: NA.26

Application: gp91 ds-tat is a cell-permeable peptide inhibitor of NADPH oxidase assembly, composed of a gp91phox-derived inhibitory sequence linked to the HIV-tat cell-penetrating peptide. The tat domain enables efficient intracellular delivery, allowing inhibition of NADPH oxidase activity inside cells. NADPH oxidase is a major source of reactive oxygen species in renal, vascular, immune, and inflammatory systems and contributes to oxidative stress-related pathology. gp91 ds-tat is widely used to study redox signaling, ROS generation, NADPH oxidase function, inflammation, kidney disease, cardiovascular dysfunction, and oxidative stress mechanisms in biochemical and cellular research models.