PMX 53c

Product Name:PMX 53c

CAS No:827600-15-7

Purity:95%

Molar Mass:780.96

Chemical Formula:C39H60N10O7

Storage:Store at -20 degrees Celsius

Sequence:FXPXAR

Target:PMX 53

Application:

PMX 53c is a peptide inhibitor of the complement component C5a receptor (C5aR), which plays a critical role in the immune response by mediating the effects of C5a, a potent pro-inflammatory molecule. By blocking the C5a-C5aR interaction, PMX 53c inhibits the inflammatory processes associated with complement activation. This peptide is of particular interest in research focused on inflammatory diseases, autoimmune conditions, and sepsis, where excessive complement activation and C5a signaling contribute to disease pathology. PMX 53c is used to explore therapeutic strategies for reducing inflammation and mitigating immune-related damage in conditions like rheumatoid arthritis and other inflammatory disorders.

Current Research:

PMX-53c is a synthetic peptide designed as an inactive control for PMX-53, a potent antagonist of the complement component 5a receptor (C5aR1 or CD88). While PMX-53 inhibits C5aR1 signaling and inflammatory responses, PMX-53c lacks this activity, serving as a crucial negative control in experimental studies. This design ensures that the effects observed with PMX-53 are specifically attributed to its antagonism of C5aR1 rather than off-target effects.
Structural Features
PMX-53c closely resembles PMX-53 in structure but includes modifications that eliminate its ability to interact effectively with C5aR1. These structural changes allow PMX-53c to be used as a benchmark for validating the specificity of PMX-53 in modulating complement system activity.
Research Applications
In immunological and inflammatory studies, PMX-53c plays a vital role in verifying the specificity of PMX-53. By using PMX-53c as a negative control, researchers can distinguish between direct C5aR1-mediated effects and nonspecific actions. This distinction is critical in experiments exploring the role of C5aR1 in immune responses, such as neutrophil activation, cytokine release, and tissue inflammation.
Significance in Complement Research
PMX-53c enhances the reliability of findings related to C5aR1 by providing a rigorous control for experimental setups. Its use ensures that observed outcomes can be confidently attributed to the targeted modulation of the C5aR1 pathway.
Conclusion
PMX-53c is an indispensable tool for research into the complement system and C5aR1-mediated processes. By acting as a negative control, it strengthens the interpretability of results and aids in uncovering the therapeutic potential of C5aR1-targeted interventions in inflammatory and autoimmune diseases. Its availability in purified form supports its wide application in both in vitro and in vivo studies.

Reference:

Subramanian, H., Kashem, S. W., Collington, S. J., Qu, H., Lambris, J. D., & Ali, H. (2011). PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. Molecular pharmacology, 79(6), 1005-1013.