GRP (human)

Product Name:GRP (human)

Synonyms:Gastrin-Releasing Peptide, human

CAS No:93755-85-2

Purity:95%

Molar Mass:2859.4

Chemical Formula:C130H204N38O31S2

Storage:Store at -20 degrees Celsius

Sequence:VPLPAGGGXVLXKMYPRGNHWAVGHLM

Application:

Gastrin-Releasing Peptide (GRP, human) is a crucial regulatory peptide involved in various physiological processes, including the stimulation of gastric acid secretion, modulation of smooth muscle activity, and promotion of cellular growth. This human-derived peptide plays a significant role in neuroendocrine signaling and is particularly relevant in research focusing on gastrointestinal function, neuroendocrine tumors, and cancer biology. GRP (human) interacts with specific receptors to influence the release of gastrin and other gastrointestinal hormones. Its high purity and biological activity make GRP (human) an indispensable tool for studying the underlying mechanisms of gastrointestinal and oncological diseases.

Current Research:

Gastrin-releasing peptide (GRP) is a 27-amino acid regulatory neuropeptide that plays a crucial role in modulating various physiological processes, particularly within the gastrointestinal and central nervous systems. It is synthesized as part of a larger precursor molecule, preproGRP, which undergoes post-translational processing to yield the active peptide.
Physiological Functions
GRP exerts its effects by binding to the gastrin-releasing peptide receptor (GRPR), a G protein-coupled receptor predominantly expressed in the pancreas, stomach, adrenal cortex, and brain. Upon activation, GRPR mediates several functions:
Gastric Acid Secretion: GRP stimulates the release of gastrin from G cells in the stomach, which in turn promotes gastric acid secretion, aiding in digestion.
Smooth Muscle Contraction: It induces contraction of smooth muscle cells, influencing gastrointestinal motility and contributing to the regulation of peristalsis.
Cell Proliferation: GRP acts as a mitogen for epithelial cells, playing a role in tissue growth and repair processes.
Clinical Significance
Aberrant expression of GRP and GRPR has been implicated in various pathological conditions:
Oncogenesis: Overexpression of GRP and its receptor has been observed in several cancers, including small cell lung carcinoma, prostate, breast, and colorectal cancers. GRP functions as an autocrine growth factor in these malignancies, promoting tumor growth and inhibiting apoptosis.
Neurological Disorders: Given its expression in the central nervous system, GRP is involved in modulating circadian rhythms, stress responses, and feeding behavior. Dysregulation of GRP signaling has been associated with conditions such as anxiety and depression.
Research Applications
Human GRP serves as a valuable model for studying the peptide's physiological and pathological roles due to its similarity to GRP in other species. Investigations utilizing human GRP have enhanced the understanding of gastrointestinal regulation and provided insights into the development of GRP-targeted therapies.
In summary, human GRP is a critical neuropeptide involved in the modulation of gastrointestinal functions and has significant implications in both health and disease. Ongoing research continues to elucidate its diverse roles, contributing to advancements in medical science and therapeutic development.

Reference:

Tittarelli, F., & Moriconi, G. (2010). Use of GRP industrial by-products in cement based composites. Cement and Concrete Composites, 32(3), 219-225.