GRP (porcine)

Product Name:GRP (porcine)

Synonyms:Gastrin releasing peptide, porcine

CAS No:74815-57-9

Purity:95%

Molar Mass:2805.3

Chemical Formula:C126H198N38O31S2

Storage:Store at -20 degrees Celsius

Sequence:APVSVGGGTVLAKMYPRGNHWAVGHLM

Application:

Gastrin-Releasing Peptide (GRP, porcine) is a bioactive peptide involved in various physiological processes, including the regulation of gastric acid secretion, smooth muscle contraction, and cellular growth. This peptide is derived from porcine sources and is particularly useful in studies related to gastrointestinal function, neuroendocrine signaling, and cancer research. GRP (porcine) binds to specific receptors, stimulating the release of gastrin and influencing the activity of various gastrointestinal hormones. With its high purity and biological relevance, GRP (porcine) is an essential tool for researchers exploring the mechanisms underlying gastrointestinal disorders, cancer, and related therapeutic interventions.

Current Research:

Gastrin-releasing peptide (GRP) is a 27-amino acid neuropeptide originally isolated from porcine gastric tissue. It plays a pivotal role in the regulation of gastrointestinal functions and exhibits structural homology to amphibian bombesin. Structure and Distribution GRP is synthesized as part of a larger precursor molecule, preproGRP, which undergoes post-translational processing to yield the active peptide. In porcine species, GRP is predominantly found in the Physiological Functions GRP exerts its effects by binding to specific G protein-coupled receptors, primarily the GRP receptor (GRPR). This interaction stimulates the release of gastrin from G cells in the stomach, leading to increased gastric acid secretion. Additionally, GRP influences smooth muscle contraction and epithelial cell proliferation within the gastrointestinal tract. Clinical Significance Aberrant expression of GRP and its receptors has been implicated in various pathological conditions, including certain cancers. Elevated levels of GRP have been observed in tumors such as small cell lung carcinoma, suggesting a role in tumor growth and progression. Consequently, GRP and GRPR are considered potential targets for therapeutic intervention in oncology. Research Applications Porcine GRP serves as a valuable model for studying the peptide's physiological and pathological roles due to its similarity to human GRP. Investigations utilizing porcine GRP have enhanced the understanding of gastrointestinal regulation and provided insights into the development of GRP-targeted therapies. In summary, porcine GRP is a critical neuropeptide involved in the modulation of gastrointestinal functions and has significant implications in both health and disease. Ongoing research continues to elucidate its diverse roles, contributing to advancements in medical science and therapeutic development.

Reference:

Ischia, J., Patel, O., Bolton, D., Shulkes, A., & Baldwin, G. S. (2014). Expression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues. BJU international, 113, 40-47.