Product Name:VIP (guinea pig)
CAS No:96886-24-7
Purity:95%
Molar Mass:3344.9
Chemical Formula:C147H239N43O42S2
Storage:Store at -20 degrees Celsius
Sequence:HSDALFTDTYTRLRKQMAMKKYLNSVLN
Application:
VIP (guinea pig), or Vasoactive Intestinal Peptide, is a 28-amino acid neuropeptide that plays a critical role in various physiological processes, particularly in the regulation of smooth muscle activity, blood flow, and secretion in the gastrointestinal tract. In guinea pigs, VIP is also involved in modulating immune responses, circadian rhythms, and neurotransmission. It exerts its effects by binding to specific receptors, leading to the relaxation of smooth muscles, dilation of blood vessels, and stimulation of enzyme secretion. Due to its wide-ranging biological activities, VIP (guinea pig) is extensively studied in research related to gastrointestinal, respiratory, and cardiovascular systems, as well as in neurobiology.
Current Research:
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide that functions as a neurotransmitter and neuromodulator, exerting a wide range of physiological effects. In guinea pigs, the amino acid sequence of VIP is:
His-Ser-Asp-Ala-Leu-Phe-Thr-Asp-Thr-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Met-Lys-Lys-Tyr-Leu-Asn-Ser-Val-Leu-Asn-NH?
This sequence is highly conserved across species, underscoring its critical biological roles.
Physiological Functions:
Vasodilation: VIP induces relaxation of vascular smooth muscle, leading to the dilation of blood vessels and a subsequent decrease in blood pressure.
Bronchodilation: It relaxes bronchial smooth muscle, thereby expanding the airways and facilitating improved airflow in the respiratory system.
Smooth Muscle Relaxation: VIP modulates gastrointestinal motility by relaxing smooth muscles in the gastrointestinal tract, which aids in digestive processes.
Neuroprotection: VIP exhibits neuroprotective properties, partly by stimulating glial cells to release activity-dependent neurotrophic factors, which support neuronal survival and function.
Research Applications:
Due to its diverse physiological effects, VIP is extensively utilized in scientific research to investigate:
Cardiovascular Regulation: Studies focus on its role in modulating vascular tone and blood pressure.
Respiratory Function: Research explores its potential therapeutic applications in conditions like asthma and chronic obstructive pulmonary disease (COPD) due to its bronchodilatory effects.
Gastrointestinal Motility Disorders: Investigations aim to understand its involvement in disorders such as irritable bowel syndrome (IBS) and other functional gastrointestinal diseases.
Neurodegenerative Diseases: Given its neuroprotective actions, VIP is studied for potential treatments of neurodegenerative conditions like Alzheimer's and Parkinson's diseases.
In summary, Vasoactive Intestinal Peptide in guinea pigs serves as a crucial modulator of various physiological systems, and its conserved structure across species makes it a valuable subject in biomedical research.
Reference:
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