Nocistatin (bovine)

Product Name:Nocistatin (bovine)

Synonyms:AKOS024456394

CAS No:208253-85-4

Purity:95%

Molar Mass:1927.1

Chemical Formula:C82H135N21O32

Storage:Store at -20 degrees Celsius

Sequence:TEPGLEEVGEIEQKQLQ

Application:

Nocistatin (bovine) is a naturally occurring neuropeptide derived from the precursor protein prepronociceptin in bovine species. This peptide plays a crucial role in modulating pain and sensory perception by counteracting the effects of nociceptin, another peptide involved in pain transmission. Nocistatin inhibits nociceptin-induced hyperalgesia, making it a significant focus of research in pain management and neurobiology. It is also studied for its potential regulatory effects on inflammation, immune responses, and neuroprotective activities. Nocistatin (bovine) is an essential tool for researchers exploring the complex mechanisms of pain modulation and the development of novel analgesic therapies.

Current Research:

Nocistatin (bovine) is a 17-amino acid neuropeptide derived from the same precursor protein as nociceptin, also known as orphanin FQ. Unlike nociceptin, which facilitates pain transmission, nocistatin functions as an endogenous antagonist, inhibiting nociceptin-induced hyperalgesia and allodynia. This opposing role suggests that nocistatin modulates pain perception by counteracting the effects of nociceptin. In vitro studies have demonstrated that nocistatin can reverse nociceptin's inhibition of glutamate release in rat brain slices, indicating its potential to modulate excitatory neurotransmission. Additionally, nocistatin has been shown to inhibit the release of 5-hydroxytryptamine (serotonin) in the mouse neocortex through presynaptic Gi/o protein-linked pathways, further highlighting its role in neurotransmitter regulation. The sequence of bovine nocistatin is TEPGLEEVGEIEQKQLQ. This sequence is conserved across species, underscoring its physiological importance. For research purposes, nocistatin (bovine) is available in synthetic form and is typically stored desiccated at -20 degrees Celsius to maintain stability. In summary, nocistatin (bovine) is a critical modulator of pain pathways, offering valuable insights into the complex mechanisms of pain transmission and potential therapeutic targets for pain management.

Reference:

Okuda-Ashitaka, E., & Ito, S. (2000). Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor. Peptides, 21(7), 1101-1109.