[Ala17]-MCH

Product Name: [Ala17]-MCH

CAS No: 359784-84-2

Purity: 95%

Molar Mass: 2271.7

Chemical Formula: C97H155N29O26S4

Storage: Store at -20??

Sequence: DFDMLRCMLGRVYRPCAQV

Target: melanin-concentrating hormone

Application: [Ala17]-MCH is an analog of melanin-concentrating hormone (MCH), where alanine replaces the amino acid at position 17. MCH is a neuropeptide that regulates appetite and energy homeostasis by binding to MCH receptors in the brain, influencing feeding behavior and energy expenditure. [Ala17]-MCH is often used in research to study the physiological roles of MCH and its receptors. It is utilized in pharmacological studies focused on obesity, metabolic disorders, and potential therapeutic interventions targeting the MCH system to regulate body weight and metabolism.

Current Research:

[Ala17]-MCH is a synthetic analog of melanin-concentrating hormone (MCH), wherein the 17th amino acid, methionine, is substituted with alanine. This modification enhances its selectivity and potency as an agonist for the MCH receptor 1 (MCHR1), a G-protein-coupled receptor implicated in the regulation of feeding behavior, energy homeostasis, and emotional responses.
In metabolic research, [Ala17]-MCH has been utilized to investigate the role of MCHR1 in energy balance. Administration of this analog in rodent models has been shown to stimulate food intake and promote adiposity, effects that are mediated through MCHR1 activation. These findings suggest that [Ala17]-MCH can serve as a valuable tool for studying the mechanisms underlying obesity and metabolic disorders.
Beyond its metabolic effects, [Ala17]-MCH has been explored in the context of mood regulation. Studies indicate that MCHR1 activation by [Ala17]-MCH influences emotional behaviors, with potential implications for understanding the pathophysiology of mood disorders such as depression and anxiety.
The specificity of [Ala17]-MCH for MCHR1 makes it a critical agent in pharmacological research, enabling the precise delineation of MCHR1-mediated pathways. Its application extends to the development of therapeutic strategies targeting MCHR1 for conditions related to energy imbalance and mood dysregulation.
In summary, [Ala17]-MCH serves as a potent and selective MCHR1 agonist with significant implications in the study of metabolic and emotional regulation. Its ability to modulate feeding behavior and emotional responses positions it as a promising candidate for further investigation in the development of treatments for metabolic and mood disorders.

Reference: Liu, J. J., Tsien, R. W., & Pang, Z. P. (2022). Hypothalamic melanin-concentrating hormone regulates hippocampus-dorsolateral septum activity. Nature neuroscience, 25(1), 61-71.