Hemokinin 1 (mouse)

Product Name: Hemokinin 1 (mouse)

CAS No: 208041-90-1

Molar Mass: 1413.7

Chemical Formula: C61H100N22O15S

Storage: Store at -20 degrees Celsius

Sequence: RSRTRQFYGLM

Purity: 95%

Application: Hemokinin-1 is a peptide belonging to the tachykinin family, known for its role in modulating immune responses and hematopoiesis. It binds to the neurokinin-1 receptor (NK1R), influencing the release of cytokines and chemokines, which are critical in immune cell communication and inflammation. Hemokinin-1 is involved in various physiological processes, including pain perception, stress response, and regulation of blood cell production. Its unique action on the immune system and inflammation makes Hemokinin-1 a valuable target for research in immunology, oncology, and inflammatory diseases, offering potential therapeutic applications for conditions like asthma, autoimmune disorders, and cancer.

Current Research:

Hemokinin-1 (HK-1), a member of the tachykinin family, is a bioactive peptide encoded by the Tac4 gene. While structurally similar to substance P, HK-1 exhibits distinct tissue distribution and biological functions, making it a significant focus in immunology, neuroscience, and pain research. It binds preferentially to the neurokinin-1 receptor (NK1R), mediating its diverse physiological effects. Mechanism of Action HK-1 interacts with NK1R, triggering intracellular signaling pathways that influence immune responses, sensory processing, and inflammation. Its high affinity for NK1R and unique receptor dynamics compared to other tachykinins distinguish it as a specialized modulator in various biological systems. Applications in Research Immunology and Inflammation HK-1 is predominantly expressed in immune cells, such as macrophages and dendritic cells, and plays a pivotal role in regulating inflammatory responses. It has been shown to enhance cytokine production, modulate leukocyte migration, and influence antigen presentation. These properties position HK-1 as a critical molecule in studying inflammatory diseases and immune modulation. Pain and Sensory Processing HK-1 contributes to nociception by modulating pain signaling pathways in sensory neurons. Its role in the peripheral and central nervous systems highlights its potential as a target for developing analgesic therapies for chronic pain conditions. Gastrointestinal and Respiratory Systems HK-1 has been implicated in regulating smooth muscle contraction and inflammatory responses in the gastrointestinal and respiratory tracts. Research in these areas explores its involvement in conditions such as asthma, irritable bowel syndrome, and other inflammatory disorders. Oncology Emerging studies suggest that HK-1 may influence tumor progression and the tumor microenvironment through its effects on inflammation and cell proliferation, offering potential insights for cancer research. Future Directions Research on HK-1 is focused on elucidating its receptor interactions, tissue-specific roles, and therapeutic potential. The development of HK-1 analogs or NK1R modulators could pave the way for innovative treatments for immune-mediated diseases, pain disorders, and certain cancers. For researchers, hemokinin-1 provides a unique perspective on tachykinin biology, offering opportunities to advance understanding in immunology, sensory regulation, and therapeutic development.

Reference:

Hajna, Z., Borbély, É., Kemény, Á., Botz, B., Kereskai, L., Szolcsányi, J., … & Helyes, Z. (2015). Hemokinin-1 is an important mediator of endotoxin-induced acute airway inflammation in the mouse. Peptides, 64, 1-7.