Neurokinin A (porcine)

Product Name:Neurokinin A (porcine)

Synonyms:Neuromedin L

CAS No:86933-74-6

Purity:95%

Molar Mass:1133.3

Chemical Formula:C50H80N14O14S

Storage:Store at -20 degrees Celsius

Sequence:HKTDSFVGLM

Application:

Neurokinin A (porcine) is a naturally occurring neuropeptide belonging to the tachykinin family, isolated from porcine tissue. It plays a vital role in various physiological processes, including the modulation of pain, smooth muscle contraction, and inflammation. Neurokinin A exerts its effects primarily by binding to the neurokinin-2 (NK2) receptor, which is widely distributed in the central and peripheral nervous systems. This peptide is extensively used in research to study its role in gastrointestinal motility, respiratory function, and neurogenic inflammation. Neurokinin A (porcine) is also valuable in the development of therapeutic agents targeting conditions such as asthma, irritable bowel syndrome, and other inflammatory disorders.

Current Research:

Neurokinin A (NKA) is a member of the tachykinin family of neuropeptides, which are characterized by a common C-terminal sequence and are involved in various physiological processes. NKA was first isolated from porcine spinal cord in 1983 by von Euler and Gaddum.
The primary structure of NKA is highly conserved across mammalian species, sharing the C-terminal sequence Phe-X-Gly-Leu-Met-NH?. This conservation suggests a fundamental role in physiological functions. In aqueous solutions, NKA adopts an extended conformation; however, in the presence of micelles, which mimic cell membranes, it forms an alpha-helical structure in its central core (Asp?-Met1?).
NKA is derived from the preprotachykinin-1 (PPT1) gene, which, through alternative splicing, produces multiple peptides, including substance P and NKA. These peptides are involved in modulating pain transmission, smooth muscle contraction, and inflammatory responses.
Functionally, NKA acts as a potent bronchoconstrictor, more so than substance P, indicating its significant role in respiratory physiology. Additionally, NKA engages neurokinin-1 receptors to induce NF-??B-dependent gene expression in murine macrophages, implicating the ERK1/2 and PI 3-kinase/Akt pathways.
In summary, Neurokinin A is a critical neuropeptide with conserved structural features and diverse physiological roles, particularly in modulating smooth muscle activity and inflammatory responses.

Reference:

Czelejewska, W., Zmijewska, A., Dziekonski, M., & Okrasa, S. (2020). The role of neurokinin A and its receptor in the regulation of prolactin secretion by the anterior pituitary of cyclic pigs. Reproduction in Domestic Animals, 55(5), 604-612.