[Leu31,Pro34]-Neuropeptide Y (human, rat)

Product Name:[Leu31,Pro34]-Neuropeptide Y (human, rat)

CAS No:132699-73-1

Purity:95%

Molar Mass:4241

Chemical Formula:C189H284N54O56S

Storage:Store at -20 degrees Celsius

Sequence:YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY

Application:

[Leu³¹,Pro³⁴]-Neuropeptide Y (human, rat) is a synthetic analog of the naturally occurring Neuropeptide Y (NPY), modified at positions 31 and 34 with leucine and proline, respectively. These specific modifications enhance the peptide's selectivity and stability, making it a valuable tool in studying NPY receptor subtypes, particularly the Y1 receptor. Neuropeptide Y is involved in regulating appetite, stress responses, and cardiovascular functions. The [Leu³¹,Pro³⁴] analog is commonly used in research to explore the physiological roles of NPY, especially in the context of metabolic disorders, anxiety, and cardiovascular diseases.

Current Research:

[Leu³¹,Pro³⁴]-Neuropeptide Y (NPY) is a synthetic analog of Neuropeptide Y, designed with leucine and proline substitutions at positions 31 and 34, respectively. This modification enhances its selectivity and potency for the Y1 receptor subtype while reducing its affinity for other NPY receptor subtypes, such as Y2.

Mechanism of Action
[Leu³¹,Pro³⁴]-NPY acts as a highly selective agonist for Y1 receptors, which are G protein-coupled receptors. Activation of Y1 receptors results in the inhibition of adenylyl cyclase, leading to decreased cyclic AMP (cAMP) levels and modulation of intracellular calcium signaling. This selectivity allows researchers to specifically study Y1 receptor-mediated physiological processes without interference from Y2 or other subtypes.

Physiological Roles
Vasoconstriction:
Through Y1 receptor activation, [Leu³¹,Pro³⁴]-NPY promotes vasoconstriction, regulating vascular tone and blood pressure.

Appetite Regulation:
Y1 receptors in the hypothalamus mediate the orexigenic effects of NPY, promoting food intake and energy storage.

Stress and Anxiety:
Y1 receptor activity modulates stress responses and emotional regulation, playing a role in anxiety-like behaviors.

Cell Proliferation:
Y1 receptor signaling influences cellular proliferation in specific tissues, including bone and adipose tissue.

Research Applications
Receptor Pharmacology:
[Leu³¹,Pro³⁴]-NPY is widely used in studies to characterize the Y1 receptor, its signaling pathways, and its physiological roles.

Cardiovascular Studies:
Its vasoconstrictive properties make it a valuable tool for investigating blood pressure regulation and vascular diseases.

Appetite and Metabolism Research:
The analog is used to explore the role of Y1 receptors in feeding behavior and energy homeostasis, contributing to obesity and metabolic disorder research.

Stress and Behavior Studies:
Its selective activation of Y1 receptors aids in understanding stress responses and developing therapeutics for anxiety and depression.

Conclusion
[Leu³¹,Pro³⁴]-Neuropeptide Y is a crucial research tool for selectively studying Y1 receptor-mediated functions. Its high specificity and potency enable detailed investigations into physiological and pathological processes, advancing our understanding of cardiovascular regulation, appetite control, and stress-related disorders.

Reference:

Gobbi, M., Mennini, T., & Vezzani, A. (1999). Autoradiographic Reevaluation of the Binding Properties of 125I‐[Leu31, Pro34] Peptide YY and 125I‐Peptide YY3‐36 to Neuropeptide Y Receptor Subtypes in Rat Forebrain. Journal of neurochemistry, 72(4), 1663-1670.