Neuropeptide Y (porcine)

Product Name:Neuropeptide Y (porcine)

CAS No:83589-17-7

Purity:95%

Molar Mass:4255

Chemical Formula:C190H286N54O58

Storage:Store at -20 degrees Celsius

Sequence:YPSKPDNPGEDAPAEDLARYYSALRHYINLITRERY

Application:

Neuropeptide Y (porcine) is a 36-amino acid peptide that belongs to the neuropeptide Y family, known for its role in various physiological processes, including appetite regulation, energy balance, and stress response. In porcine species, this neuropeptide is primarily found in the brain and nervous system, where it acts as a potent neurotransmitter. Neuropeptide Y influences food intake, circadian rhythms, and cardiovascular function by interacting with specific receptors in the body. Due to its significant impact on metabolic and stress-related pathways, Neuropeptide Y (porcine) is widely studied in research focused on obesity, anxiety disorders, and cardiovascular diseases.

Current Research:

Neuropeptide Y (NPY) is a 36-amino acid peptide widely distributed in the central and peripheral nervous systems. It belongs to the pancreatic polypeptide family and is highly conserved across species, including porcine. Porcine NPY is identical in sequence to human NPY, making it a widely used model in research.

Mechanism of Action
NPY exerts its effects by binding to specific G protein-coupled receptors (Y1, Y2, Y4, Y5, and Y6). These receptors mediate a variety of intracellular signaling cascades, including the inhibition of adenylyl cyclase and the activation of mitogen-activated protein kinase (MAPK) pathways. Through these mechanisms, NPY modulates numerous physiological processes.

Physiological Roles
Energy Homeostasis and Appetite Regulation:
NPY is a potent stimulator of food intake and plays a critical role in energy balance. It is secreted in response to energy deficit and acts on the hypothalamus to promote feeding behavior.

Stress and Anxiety:
NPY has anxiolytic effects, reducing stress responses by modulating the activity of the hypothalamic-pituitary-adrenal (HPA) axis.

Cardiovascular Function:
NPY is involved in regulating blood pressure and heart rate by modulating sympathetic nervous system activity and causing vasoconstriction.

Neuroprotection:
In the central nervous system, NPY exhibits neuroprotective effects, influencing neuronal survival and synaptic plasticity.

Metabolic Regulation:
It influences glucose homeostasis and lipid metabolism, playing a role in conditions like diabetes and obesity.

Research Applications
Neuroscience: NPY is used to study its role in mood regulation, neuroprotection, and neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases.
Metabolic Studies: Its role in appetite and energy balance makes it a target for obesity and diabetes research.
Cardiovascular Research: NPY is investigated for its effects on blood pressure regulation and potential therapeutic applications in hypertension.
Stress and Behavior: Studies focus on its involvement in anxiety, depression, and stress-related disorders.
Conclusion
Porcine Neuropeptide Y is a versatile research tool for studying a broad range of physiological processes, from appetite regulation to cardiovascular and neuroprotective functions. Its conserved sequence and functional similarities to human NPY make it invaluable in advancing biomedical research and therapeutic development.

Reference:

Roddy, D. R., Yaksh, T. L., Aimone, L. D., & Go, V. L. W. (1990). Distribution of neuropeptide Y in the spinal cords of cat, dog, rat, man and pig. Regulatory peptides, 29(2-3), 81-92.