Product Name:Hexapeptide-10/Serilesine
Form:Acetate salt
Purity:98%
Storage:2-8 degree Celsius
Cas No:146439-94-3
Molar Mass:615.77
Chemical Formula:C28H53N7O8
IUPAC Name:(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
SMILES:CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](CO)N
InChIKey:OFGVZFQUFJYSGS-CPDXTSBQSA-N
InChI:InChI=1S/C28H53N7O8/c1-8-16(6)22(35-24(38)18(30)13-36)27(41)32-19(11-9-10-12-29)25(39)33-20(14(2)3)26(40)31-17(7)23(37)34-21(15(4)5)28(42)43/h14-22,36H,8-13,29-30H2,1-7H3,(H,31,40)(H,32,41)(H,33,39)(H,34,37)(H,35,38)(H,42,43)/t16-,17-,18-,19-,20-,21-,22-/m0/s1
Sequence: H-Ser-ile-lys-val-ala-val-OH
Application:Hexapeptide-10 (Serilesine) is a bioactive peptide designed to enhance skin firmness, elasticity, and overall structure by stimulating cell adhesion proteins such as laminin-5, integrins, and collagen synthesis. This peptide strengthens the dermal-epidermal junction (DEJ), helping to improve skin density and reduce sagging. Clinical studies have shown that Hexapeptide-10 can visibly smooth and firm the skin within weeks, making it a valuable ingredient in anti-aging, firming, and restructuring skincare products. Commonly found in serums, creams, and eye treatments, Serilesine is particularly effective in addressing mature, sagging, or thinning skin, restoring its youthful plumpness and resilience.
Current Research:
Hexapeptide-10, commercially known as Serilesine, is a synthetic peptide specifically developed to improve skin adhesion, structure, and firmness. It has gained attention in anti-aging and regenerative dermatology due to its ability to reinforce the dermal-epidermal junction (DEJ), which weakens with age and leads to sagging skin and loss of elasticity.
Mechanism of Action in Skin Firmness and Elasticity
The dermal-epidermal junction (DEJ) is a crucial structural component that connects the epidermis (outer skin layer) with the dermis (deeper skin layer). As skin ages, this junction deteriorates, leading to thinning skin, reduced elasticity, and visible sagging.
Hexapeptide-10 stimulates key extracellular matrix proteins responsible for maintaining DEJ integrity, including:
Laminin-5 – essential for cell adhesion and maintaining skin structure.
Integrins (α6β1, α3β1) – proteins involved in cell signaling, cohesion, and tissue repair.
Collagen IV and VII – crucial for skin firmness and resilience.
A study published by Lipotec (developer of Serilesine) found that Hexapeptide-10 increased collagen IV and VII production by 30% in skin fibroblasts, leading to improved skin cohesion and firmness.
Clinical Studies and Efficacy
Multiple in vivo and in vitro studies have assessed the anti-aging and firming effects of Hexapeptide-10:
A 56-day clinical trial found that Hexapeptide-10 improved skin density and firmness by 38%, significantly reducing sagging in the jawline and cheeks.
Participants reported smoother, more elastic skin with better hydration and resilience after consistent use of Hexapeptide-10-infused creams.
This research supports the role of Serilesine as a restructuring peptide, particularly for mature skin experiencing loss of firmness, fine lines, and textural irregularities.
Comparison with Other Peptides and Firming Agents
Hexapeptide-10 differs from neuropeptides like SNAP-8 or SYN-AKE, which focus on reducing dynamic wrinkles. Instead, it targets skin cohesion and structure, making it ideal for:
Mature skin lacking elasticity
Post-menopausal skin regeneration
Firming and lifting treatments
Compared to collagen-boosting peptides like Matrixyl, Hexapeptide-10 works at a deeper structural level, strengthening cell adhesion proteins rather than just stimulating collagen production.
Future Research and Applications
Scientists are exploring Hexapeptide-10 in combination with hyaluronic acid, retinoids, and growth factors to enhance skin rejuvenation. Ongoing studies also investigate its role in wound healing and skin barrier repair.
With its proven ability to restore skin firmness, improve density, and support cell adhesion, Hexapeptide-10 (Serilesine) is a key ingredient in anti-aging, restructuring, and firming skincare formulations, particularly for sagging or mature skin.
Reference:
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