Leuphasyl

Product Name:Leuphasyl

Form:Acetate salt

Purity:98%

Storage:2-8 degree Celsius

Cas No:64963-01-5

Molar Mass:569.7

Chemical Formula:C29H39N5O7

Synonyms:Pentapeptide-18

IUPAC Name:(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid

SMILES:C[C@H](C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N

InChIKey:ZHUJMSMQIPIPTF-JMBSJVKXSA-N

InChI:InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24+/m1/s1

Sequence:Tyr-D-Ala-Gly-Phe-Leu

Application:

Leuphasyl® (Pentapeptide-18) is a neuropeptide designed to reduce expression wrinkles by modulating muscle contractions, similar to botulinum toxin but with a milder, non-paralytic effect. It works by targeting the neuromuscular synapse, inhibiting excessive neurotransmitter release, leading to smoother, relaxed skin. Clinical studies show that Leuphasyl reduces wrinkle depth and fine lines in areas prone to repetitive facial movements, such as the forehead and crow’s feet. Often combined with Argireline® (Acetyl Hexapeptide-8), it enhances anti-aging efficacy without invasive procedures. Leuphasyl is commonly used in serums, anti-wrinkle creams, and eye treatments for a more youthful and refreshed appearance.

Current Research:

Leuphasyl (Pentapeptide-18) is a synthetic pentapeptide that has gained significant attention in cosmetic dermatology for its role in reducing dynamic wrinkles. Unlike conventional neurotoxins such as botulinum toxin (Botox®), Leuphasyl provides a non-invasive, peptide-based approach to smooth fine lines and prevent wrinkle formation.

Mechanism of Action: Modulating Facial Muscle Contractions
Leuphasyl works by interfering with the nerve signal transmission that controls muscle contraction. It specifically:

Mimics enkephalins, natural peptides that regulate nerve impulses.
Binds to presynaptic neurons, modulating the release of acetylcholine, which is responsible for muscle contractions.
Reduces facial tension, smoothing fine lines without completely paralyzing facial muscles.
This mechanism makes Leuphasyl a gentler alternative to Botox, allowing for a more natural facial expression while still reducing wrinkle depth.

Clinical Studies and Efficacy
Several in vitro and in vivo studies have assessed the effectiveness of Leuphasyl in reducing expression wrinkles:

A clinical study conducted by Lipotec (the peptide’s developer) showed that a 10% Leuphasyl formulation reduced wrinkle depth by 25-30% within 30 days of use.
When combined with Argireline (Acetyl Hexapeptide-8), the peptide exhibited a synergistic effect, enhancing wrinkle-reducing efficacy by over 40% compared to either peptide alone.
These findings suggest that Leuphasyl is particularly effective when used in combination therapy with other neuropeptides or anti-aging ingredients.

Comparison with Other Anti-Wrinkle Peptides
Leuphasyl is often compared to Argireline (Acetyl Hexapeptide-8), another peptide that reduces expression wrinkles by inhibiting SNARE complex formation in nerve cells. While both peptides have similar muscle-relaxing properties, Leuphasyl’s mechanism is more enkephalin-like, meaning it mimics natural neuroregulation rather than directly interfering with synaptic activity. This results in:

A more gradual, natural wrinkle-reducing effect compared to Argireline.
No freezing effect, allowing for normal facial expressions.
Additionally, when combined with SYN-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate), another neuropeptide that mimics viper venom, Leuphasyl can further enhance muscle relaxation and anti-aging benefits.

Future Research and Applications
Ongoing research is exploring Leuphasyl’s potential in preventing early signs of aging and improving skin hydration by enhancing its combination with hyaluronic acid, collagen peptides, and antioxidants. Scientists are also looking into nano-encapsulation techniques to improve its stability and skin penetration.

With its proven ability to reduce expression wrinkles while maintaining a natural facial appearance, Leuphasyl is a key ingredient in next-generation anti-aging skincare, particularly in serums, eye creams, and neurocosmetic formulations.

Reference:

Dragomirescu, A. O., Andoni, M., Ionescu, D., & Andrei, F. (2014). The efficiency and safety of leuphasyl—a botox-like peptide. Cosmetics, 1(2), 75-81.