Biotinoyl Tripeptide-1

Product Name:Biotinoyl Tripeptide-1

Form:TFA Salt

Purity:98%

Storage:2-8 degree Celsius

Cas No:299157-54-3

Molar Mass:566.67

Chemical Formula:C24H38N8O6S

Synonyms:Biotin-GHK

IUPAC Name:(2S)-2-[[(2S)-2-[[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanoic acid

SMILES:C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)NCC(=O)N[C@@H](CC3=CN=CN3)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)N2

InChIKey:WCKVVODUWGBPQV-SOADLSRISA-N

InChI:InChI=1S/C24H38N8O6S/c25-8-4-3-5-15(23(36)37)30-22(35)16(9-14-10-26-13-28-14)29-20(34)11-27-19(33)7-2-1-6-18-21-17(12-39-18)31-24(38)32-21/h10,13,15-18,21H,1-9,11-12,25H2,(H,26,28)(H,27,33)(H,29,34)(H,30,35)(H,36,37)(H2,31,32,38)/t15-,16-,17-,18-,21-/m0/s1

Sequence:Biotin-Gly-His-Lys

Application:Biotinoyl Tripeptide-1 is a specialized peptide conjugated with biotin, designed to support hair and skin health. It functions by stimulating the production of key extracellular matrix proteins, including collagen and laminin, enhancing follicle anchoring and reducing hair loss. Additionally, this peptide strengthens hair follicles, promoting denser, fuller hair growth while improving scalp health. In skincare applications, it contributes to improved skin elasticity and resilience. Widely utilized in cosmetic formulations, Biotinoyl Tripeptide-1 is a key ingredient in anti-hair loss serums, eyelash enhancers, and rejuvenating skincare products, offering a scientifically backed approach to strengthening hair and skin structure at a cellular level.

Current Research:

Biotinoyl Tripeptide-1 has gained significant attention in cosmetic and dermatological research due to its role in promoting hair growth and improving skin health. This peptide, composed of three amino acids linked to biotin, is known for stimulating extracellular matrix proteins such as collagen IV and laminin 5, which enhance the structural integrity of hair follicles and skin.

Hair Growth and Anti-Hair Loss Effects
Several studies have demonstrated that Biotinoyl Tripeptide-1 can stimulate keratinocyte proliferation and reinforce the hair follicle anchoring structure. A study published in the International Journal of Cosmetic Science found that formulations containing Biotinoyl Tripeptide-1 improved hair density and thickness after consistent use for three months. The peptide functions by prolonging the anagen (growth) phase of the hair cycle while reducing the telogen (resting) phase, thereby preventing premature hair shedding.

Additionally, Biotinoyl Tripeptide-1 has been found to upregulate gene expression related to keratin production, a crucial component of hair structure. It is commonly included in hair serums, shampoos, and eyelash-enhancing treatments for its ability to strengthen weakened follicles and stimulate new hair growth.

Skin Health Benefits
Beyond hair applications, Biotinoyl Tripeptide-1 has been explored for its benefits in skin rejuvenation. It plays a role in enhancing collagen synthesis and improving skin elasticity, making it a popular ingredient in anti-aging skincare products. Studies indicate that this peptide can reduce the appearance of fine lines and wrinkles by reinforcing the skin’s barrier function and increasing hydration levels.

A study in Skin Pharmacology and Physiology suggested that Biotinoyl Tripeptide-1, when incorporated into anti-aging serums and creams, enhanced skin repair mechanisms and improved overall skin firmness. Its ability to modulate inflammatory pathways further contributes to its protective effects against oxidative stress and environmental damage.

Future Research and Potential Applications
While Biotinoyl Tripeptide-1 is already widely used in the cosmetic industry, ongoing research aims to optimize its efficacy in hair regrowth treatments and skin repair. Scientists are exploring its combination with other peptides and growth factors to enhance bioavailability and maximize its regenerative effects. Additionally, research into its role in treating androgenic alopecia and scalp disorders may further expand its applications in clinical dermatology.

In conclusion, Biotinoyl Tripeptide-1 continues to be a promising bioactive peptide for improving hair and skin health. Its ability to reinforce follicle anchoring, stimulate hair growth, and enhance skin elasticity makes it a valuable ingredient in modern cosmeceutical formulations.

Reference:

Wang, L., Wu, Z., Wang, X., Wang, X., Mao, J., Yan, Y., ... & Zhang, Z. (2025). Overview of Peptides and Their Potential Roles in Skin Health and Beauty. Journal of Peptide Science, 31(2), e3668.