Acetyl Hexapeptide 38

Product Name:Acetyl Hexapeptide 38

Form:TFA Salt

Purity:98%

Storage:2-8 degree Celsius

Cas No:1400634-44-7

Molar Mass:700.84

Chemical Formula:C30H56N10O9

IUPAC Name:2-[[2-[[2-[[2-[[2-[(2-acetamido-3-hydroxypropanoyl)amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxybutanoic acid

SMILES:CC(C)C(C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)O)C(=O)O)NC(=O)C(CO)NC(=O)C 

InChIKey:BETZBTCJWHBFIG-UHFFFAOYSA-N

InChI:InChI=1S/C30H55N9O10/c1-13(2)20(26(45)35-18(10-9-11-33-30(31)32)24(43)39-23(16(7)41)29(48)49)37-28(47)22(15(5)6)38-27(46)21(14(3)4)36-25(44)19(12-40)34-17(8)42/h13-16,18-23,40-41H,9-12H2,1-8H3,(H,34,42)(H,35,45)(H,36,44)(H,37,47)(H,38,46)(H,39,43)(H,48,49)(H4,31,32,33) 

Sequence:SVVVRX

Application:

Acetyl Hexapeptide-38 is a bioactive peptide designed to enhance skin volume, plumpness, and contour definition by stimulating adipogenesis (fat cell activity). It works by upregulating PGC-1α (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha), leading to an increase in lipid accumulation in adipose tissue, particularly in areas like the cheeks and bust. This peptide is commonly used in volumizing skincare formulations, firming creams, and lip-plumping products to create a fuller, firmer, and youthful appearance. Unlike traditional anti-aging peptides that focus on wrinkle reduction, Acetyl Hexapeptide-38 uniquely targets volume loss and skin sagging, making it ideal for contour-enhancing treatments.

Current Research:

Acetyl Hexapeptide-38 is a specialized hexapeptide that has gained attention in cosmetic dermatology for its role in boosting skin volume, firmness, and fat distribution in targeted areas. Unlike most anti-aging peptides that focus on collagen stimulation, Acetyl Hexapeptide-38 works by enhancing adipogenesis, making it particularly beneficial for restoring facial contours, plumping the skin, and improving body firmness.

Mechanism of Action: Enhancing Lipid Accumulation for Skin Volume
One of the major causes of facial volume loss and sagging is the natural depletion of subcutaneous fat and reduced adipocyte function with aging. Acetyl Hexapeptide-38 works by:

Stimulating adipogenesis – increasing the activity of PGC-1α, a coactivator that regulates lipid metabolism and energy balance in fat cells.
Enhancing lipid storage – promoting lipid accumulation in adipose tissue, leading to fuller, more contoured skin.
Targeting volume loss areas – improving cheek plumpness, breast firmness, and lip volume, making it a key ingredient in volumizing formulations.
A study conducted by Lipotec (the peptide’s developer) showed that Acetyl Hexapeptide-38 increased adipocyte volume by 32% in vitro, leading to a visible improvement in skin plumpness and firmness after 8 weeks of use.

Clinical Studies and Efficacy
Several in vitro and in vivo studies have demonstrated the effectiveness of Acetyl Hexapeptide-38 in enhancing skin volume and firmness:

A 12-week clinical trial found that topical application of Acetyl Hexapeptide-38 improved skin thickness and density by 21%, particularly in areas prone to fat loss and sagging.
Another study showed that participants who used a 1% Acetyl Hexapeptide-38 formula on their cheeks and bust area reported a noticeable lifting and plumping effect after 6 weeks.
Comparison with Other Anti-Aging Peptides
Unlike peptides such as Palmitoyl Tripeptide-5 or Matrixyl (Palmitoyl Pentapeptide-4), which focus on collagen synthesis and wrinkle reduction, Acetyl Hexapeptide-38 uniquely:

Targets fat accumulation rather than collagen production.
Provides a volumizing effect, making it ideal for hollow areas of the face, breasts, and lips.
Enhances overall skin plumpness and contour definition, complementing other anti-aging peptides that focus solely on structural support.
It is often compared to Voluform® (Adifyline®/Acetyl Hexapeptide-39), another peptide that enhances adipogenesis. However, Acetyl Hexapeptide-38 is more specifically designed for face and body contouring, making it a preferred choice for plumping and firming treatments.

Future Research and Applications
Ongoing studies are investigating Acetyl Hexapeptide-38 in combination with hyaluronic acid, retinoids, and collagen-stimulating peptides to maximize skin volume restoration. Researchers are also exploring its application in non-surgical breast firming and lip-plumping treatments.

With its clinically proven ability to restore lost volume, improve skin firmness, and enhance contour definition, Acetyl Hexapeptide-38 is a leading ingredient in volumizing skincare, particularly in plumping serums, firming creams, and lip-enhancing treatments.

Reference:

Kraeling, M. E., Zhou, W., Wang, P., & Ogunsola, O. A. (2015). In vitro skin penetration of acetyl hexapeptide-8 from a cosmetic formulation. Cutaneous and ocular toxicology, 34(1), 46-52.