Product Name:Snap-8 / Acetyl octapeptide-3
Form:Acetate salt
Purity:98%
Storage:2-8 degree Celsius
Cas No:868844-74-0
Molar Mass:1075.18
Chemical Formula:C41H70N16O16S
IUPAC Name:(4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
SMILES:C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)C
InChIKey:KMACPCJUCHVVGP-FNRPHRCSSA-N
InChI:InChI=1S/C41H70N16O16S/c1-19(33(67)57-27(32(43)66)18-31(64)65)50-34(68)21(6-4-15-48-40(44)45)52-35(69)22(7-5-16-49-41(46)47)53-37(71)24(8-11-28(42)59)54-39(73)26(14-17-74-3)56-38(72)25(10-13-30(62)63)55-36(70)23(51-20(2)58)9-12-29(60)61/h19,21-27H,4-18H2,1-3H3,(H2,42,59)(H2,43,66)(H,50,68)(H,51,58)(H,52,69)(H,53,71)(H,54,73)(H,55,70)(H,56,72)(H,57,67)(H,60,61)(H,62,63)(H,64,65)(H4,44,45,48)(H4,46,47,49)/t19-,21-,22-,23-,24-,25-,26-,27-/m0/s1
Sequence:Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Application:SNAP-8 (Acetyl Octapeptide-3) is an advanced anti-wrinkle peptide designed to reduce facial expression lines by modulating muscle contractions. As an extended version of Argireline (Acetyl Hexapeptide-8), SNAP-8 works by inhibiting neurotransmitter release at the neuromuscular junction, leading to a smoother, more youthful skin appearance. Clinical studies have shown that SNAP-8 can reduce wrinkle depth by up to 63% in just four weeks, making it a powerful alternative to botulinum toxin injections. It is commonly found in anti-aging serums, eye creams, and facial moisturizers, helping to prevent and diminish fine lines, especially on the forehead and around the eyes.
Current Research:
SNAP-8 (Acetyl Octapeptide-3) is an octapeptide derived from SNAP-25, a key protein involved in neurotransmitter release at the neuromuscular junction. It is an improved version of Argireline (Acetyl Hexapeptide-8) and is widely studied for its ability to reduce dynamic wrinkles caused by repeated facial expressions.
Mechanism of Action in Wrinkle Reduction
SNAP-8 works by inhibiting the release of acetylcholine, the neurotransmitter responsible for muscle contractions. By blocking the SNARE complex formation, it reduces excessive facial muscle movement, leading to smoother skin and diminished expression lines.
Compared to Argireline, SNAP-8 has been engineered for greater efficacy and stability, providing a more pronounced anti-wrinkle effect. A double-blind clinical study conducted by Lipotec, the peptide’s developer, found that a 10% concentration of SNAP-8 reduced wrinkle depth by up to 63% in just 28 days. The most significant improvements were observed on the forehead, crow’s feet, and periorbital areas, where repeated facial expressions contribute to wrinkle formation.
Comparison with Botulinum Toxin and Other Peptides
SNAP-8 offers a non-invasive alternative to botulinum toxin injections (Botox). While Botox completely blocks nerve signals to muscles, SNAP-8 modulates muscle contractions without paralyzing facial expressions, resulting in a more natural, relaxed appearance. Additionally, since it is applied topically, it avoids the risks associated with injectables.
SNAP-8 is also compared to other neuropeptides like SYN-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate) and Argireline. Research suggests that SNAP-8 outperforms Argireline by providing greater muscle relaxation and deeper wrinkle reduction, while still allowing normal facial movement.
Skin Hydration and Additional Benefits
Besides reducing wrinkles, SNAP-8 has been shown to enhance skin hydration and elasticity. By reinforcing the skin barrier, it helps retain moisture, improving skin smoothness and firmness. Its antioxidant properties further protect skin from oxidative stress and premature aging caused by environmental damage.
Future Research and Applications
Recent studies are investigating the potential of SNAP-8 in combination with hyaluronic acid, collagen peptides, and growth factors to boost its anti-aging effects. Researchers are also exploring nanotechnology-based delivery systems to enhance penetration and bioavailability for longer-lasting results.
With its proven efficacy in reducing expression lines, improving hydration, and providing a non-invasive Botox alternative, SNAP-8 remains a leading peptide in anti-aging skincare formulations, particularly in serums, eye creams, and facial treatments.
Reference:
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