SYN-AKE/Dipeptide diaminobutyroyl benzylamide diacetate

Product Name:SYN-AKE/Dipeptide diaminobutyroyl benzylamide diacetate

Form:Acetate salt

Purity:98%

Storage:2-8 degree Celsius

Cas No:823202-99-9

Molar Mass:375.46

Chemical Formula:C19H29N5O3

IUPAC Name:acetic acid;(2S)-N-[(2S)-4-amino-1-(benzylamino)-1-oxobutan-2-yl]-1-(3-aminopropanoyl)pyrrolidine-2-carboxamide

SMILES:CC(=O)O.CC(=O)O.C1C[C@H](N(C1)C(=O)CCN)C(=O)N[C@@H](CCN)C(=O)NCC2=CC=CC=C2

InChIKey:HSUGRPOJOBRRBK-SXBSVMRRSA-N

InChI:InChI=1S/C19H29N5O3.2C2H4O2/c20-10-8-15(18(26)22-13-14-5-2-1-3-6-14)23-19(27)16-7-4-12-24(16)17(25)9-11-21;2*1-2(3)4/h1-3,5-6,15-16H,4,7-13,20-21H2,(H,22,26)(H,23,27);2*1H3,(H,3,4)/t15-,16-;;/m0../s1

Sequence:H-β-Ala-Pro-Dab-NHBzl

Application:

SYN®-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate) is a biomimetic peptide designed to mimic the effects of Waglerin-1, a neurotoxin found in temple viper venom, which helps reduce facial muscle contractions and smooth wrinkles. This synthetic peptide temporarily inhibits muscle activity, similar to botulinum toxin, making it a powerful ingredient in anti-aging skincare. Clinical studies have shown that SYN-AKE can reduce wrinkle depth and improve skin smoothness within weeks of use. It is widely incorporated into anti-wrinkle serums, creams, and eye treatments, offering a non-invasive solution for reducing fine lines and preventing expression wrinkles, particularly on the forehead and around the eyes.

Current Research:

SYN®-AKE is a patented biomimetic peptide developed to imitate the muscle-relaxing properties of Waglerin-1, a neurotoxin found in the venom of the temple viper (Tropidolaemus wagleri). It has gained popularity in the cosmetic industry due to its ability to reduce dynamic wrinkles and provide a temporary smoothing effect on the skin.

Mechanism of Action in Wrinkle Reduction
SYN-AKE functions as a neuromuscular blocking agent, targeting acetylcholine receptors at the neuromuscular junction. By inhibiting the uptake of sodium ions in muscle cells, it prevents excessive facial muscle contractions, similar to the action of botulinum toxin (Botox). This results in a relaxed skin surface, reducing the appearance of expression lines and preventing new wrinkles from forming.

Clinical studies have demonstrated that SYN-AKE significantly reduces wrinkle depth, particularly on the forehead and crow’s feet areas, within 28 days of consistent use. A study conducted by Pentapharm Ltd., the developer of SYN-AKE, found that a 4% SYN-AKE formulation led to a 52% reduction in wrinkle depth after 28 days.

Comparison with Botulinum Toxin and Other Peptides
While SYN-AKE provides a temporary muscle-relaxing effect, it does not paralyze muscles permanently like botulinum toxin. This makes it a safer, non-invasive alternative for individuals who want anti-aging benefits without injections. Unlike Botox, which requires professional administration, SYN-AKE is designed for topical application, making it accessible for daily skincare use.

Additionally, SYN-AKE is often compared to Argireline (Acetyl Hexapeptide-8), another peptide that works by relaxing facial muscles. However, SYN-AKE has been found to work faster and more effectively at reducing deep expression wrinkles.

Additional Benefits: Hydration and Skin Elasticity
Beyond wrinkle reduction, SYN-AKE has been shown to enhance skin hydration and elasticity. It improves skin barrier function, preventing moisture loss and maintaining a smooth, youthful appearance. It also reduces oxidative stress, protecting skin cells from environmental damage.

Future Research and Applications
Ongoing studies are investigating the potential of SYN-AKE in combination with other peptides and active ingredients like hyaluronic acid, collagen-boosting peptides, and antioxidants to enhance its anti-aging effects. Researchers are also exploring its long-term efficacy and potential applications in preventing premature aging.

With its proven ability to reduce expression wrinkles, improve skin smoothness, and act as a non-invasive alternative to Botox, SYN-AKE remains a leading innovation in peptide-based skincare, particularly in anti-aging formulations.

Reference:

Gok, B., Budama-Kilinc, Y., & Kecel-Gunduz, S. (2024). Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests. Journal of Biomolecular Structure and Dynamics, 42(10), 5015-5029.