Myristoyl pentapeptide-17

Product Name:Myristoyl pentapeptide-17

Form:Acetate salt

Purity:98%

Storage:2-8 degree Celsius

Cas No:959610-30-1

Molar Mass:796.14

Chemical Formula:C41H81N9O6

IUPAC Name:N-[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]tetradecanamide

SMILES:CCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N

InChIKey:NFPWMUOQSJXGGZ-ZZTWKDBPSA-N

InChI:InChI=1S/C41H81N9O6/c1-5-6-7-8-9-10-11-12-13-14-15-25-36(51)47-33(23-17-20-27-43)39(54)50-35(29-30(2)3)41(56)46-31(4)38(53)49-34(24-18-21-28-44)40(55)48-32(37(45)52)22-16-19-26-42/h30-35H,5-29,42-44H2,1-4H3,(H2,45,52)(H,46,56)(H,47,51)(H,48,55)(H,49,53)(H,50,54)/t31-,32-,33-,34-,35-/m0/s1

Sequence:Myr-Lys-Leu-Ala-Lys-Lys-NH2

Application:

Myristoyl Pentapeptide-17 is a specialized eyelash and eyebrow-enhancing peptide designed to stimulate keratin production, promoting thicker, longer, and fuller lashes and brows. By nourishing hair follicles and strengthening the lash structure, this peptide helps reduce breakage and improve hair retention. It works by enhancing the expression of keratin genes, leading to denser and healthier-looking lashes over time. Often included in lash growth serums, brow enhancers, and volumizing mascaras, Myristoyl Pentapeptide-17 provides a non-irritating, safe alternative to prostaglandin-based lash growth treatments, making it an ideal choice for long-term eyelash conditioning and enhancement.

Current Research:

Myristoyl Pentapeptide-17 is a bioactive pentapeptide that has been extensively studied for its role in promoting eyelash and eyebrow growth. Unlike prostaglandin analogs (e.g., bimatoprost), which force hair follicles into an extended growth phase but may cause eye irritation and pigmentation changes, this peptide works by stimulating keratin production to naturally enhance the density and length of lashes and brows.

Mechanism of Action in Eyelash and Eyebrow Growth
The primary mechanism of Myristoyl Pentapeptide-17 involves increasing keratin gene expression, leading to improved:

Hair follicle strength – reducing lash and brow breakage.
Keratinocyte proliferation – enhancing the production of keratin, the protein responsible for hair structure.
Hair retention – helping eyelashes and brows stay in the anagen (growth) phase longer.
A study conducted by DSM (a leading cosmeceutical company) found that Myristoyl Pentapeptide-17 can increase keratin gene activity by up to 160%, leading to visibly thicker, healthier lashes in as little as four weeks.

Clinical Studies and Efficacy
Several in vivo and in vitro studies have evaluated the eyelash-enhancing potential of Myristoyl Pentapeptide-17:

In a 6-week clinical trial, participants using a 2% Myristoyl Pentapeptide-17 formula experienced a 25-30% increase in lash length and thickness compared to the control group.
Users also reported stronger, more resilient lashes, reducing the need for synthetic extensions or lash lifts.
Unlike prostaglandin-based lash serums (e.g., Latisse), Myristoyl Pentapeptide-17 does not alter iris pigmentation or cause redness, making it a safer, irritation-free alternative for daily use.

Comparison with Other Lash-Enhancing Ingredients
Compared to biotinoyl tripeptide-1 (another lash-enhancing peptide), Myristoyl Pentapeptide-17 is particularly effective at boosting keratin production, while biotinoyl tripeptide-1 focuses more on improving follicle anchoring. Many modern eyelash serums now combine both peptides for maximum lash growth and strength.

Additionally, it is often combined with panthenol (pro-vitamin B5) and hyaluronic acid in formulations to provide hydration, nourishment, and protection to fragile lashes.

Future Research and Applications
Ongoing research is exploring Myristoyl Pentapeptide-17 in combination with plant-derived growth factors to further enhance its lash-lengthening effects. Researchers are also investigating its potential applications in scalp hair regrowth treatments and eyebrow-thickening formulations.

With its clinically proven ability to strengthen, thicken, and promote natural lash and brow growth, Myristoyl Pentapeptide-17 continues to be a leading ingredient in eyelash and eyebrow serums, mascaras, and hair-enhancing treatments.

Reference:

Sachdev, M., Velugotla, K., Revanker, S., & Somasekhar, G. (2020). An open-label, single-center, safety and efficacy study of eyelash polygrowth factor serum. The Journal of clinical and aesthetic dermatology, 13(2), 61.