Acetyl Tetrapeptide-5/Eyeseryl

Product Name:Acetyl Tetrapeptide-5/Eyeseryl

Form:Acetate salt

Purity:98%

Storage:2-8 degree Celsius

Cas No:820959-17-9

Molar Mass:492.48

Chemical Formula:C20H28N8O7

IUPAC Name:(2S)-2-[[(2S)-2-[[(2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid

SMILES:CC(=O)NCCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CN=CN2)C(=O)O

InChIKey:ROTFCACGLKOUGI-JYJNAYRXSA-N

InChI:InChI=1S/C20H28N8O7/c1-11(30)23-3-2-17(31)26-14(4-12-6-21-9-24-12)18(32)28-16(8-29)19(33)27-15(20(34)35)5-13-7-22-10-25-13/h6-7,9-10,14-16,29H,2-5,8H2,1H3,(H,21,24)(H,22,25)(H,23,30)(H,26,31)(H,27,33)(H,28,32)(H,34,35)/t14-,15-,16-/m0/s1

Sequence:Ac-Beta-Ala-His-Ser-His-OH

Application:

Acetyl Tetrapeptide-5, commonly known as Eyeseryl, is a multifunctional peptide widely used in cosmetic formulations to reduce puffiness, dark circles, and signs of fatigue around the eyes. It works by improving lymphatic drainage, reducing water retention, and enhancing skin elasticity. Additionally, Eyeseryl has anti-glycation properties, which help prevent collagen degradation and improve skin firmness. Studies have shown that this peptide effectively diminishes under-eye bags and smooths the periorbital area within weeks of use. Due to its hydrating and anti-inflammatory properties, Acetyl Tetrapeptide-5 is a key ingredient in eye creams, serums, and anti-aging skincare products designed for a refreshed appearance.

Current Research:

Acetyl Tetrapeptide-5, marketed under the brand name Eyeseryl, is a bioactive peptide extensively studied for its ability to reduce puffiness and dark circles around the eyes. Its primary mechanism of action involves reducing fluid accumulation (edema) in the periorbital area while also improving skin elasticity and hydration.

Mechanisms of Action in Reducing Eye Puffiness and Dark Circles
One of the main causes of under-eye puffiness is water retention due to poor lymphatic drainage. Acetyl Tetrapeptide-5 enhances microcirculation, promoting better fluid balance and reducing visible swelling. Studies have shown that this peptide helps inhibit vascular permeability, preventing excess fluid buildup in the delicate skin under the eyes.

Furthermore, Acetyl Tetrapeptide-5 exhibits anti-glycation properties by preventing the degradation of collagen and elastin, which are essential for maintaining skin firmness. Glycation, a process in which sugars bind to proteins and create stiff, damaged skin, is a common factor in premature aging. By inhibiting glycation, Eyeseryl helps maintain the skin’s natural elasticity, reducing the appearance of fine lines and sagging.

A clinical study conducted by Lipotec demonstrated that a 10% concentration of Eyeseryl applied twice daily led to a 70% reduction in eye puffiness in volunteers after 15 days. This evidence supports its effectiveness in visibly rejuvenating the under-eye area within a short period.

Hydrating and Anti-Inflammatory Properties
Another key benefit of Acetyl Tetrapeptide-5 is its moisturizing effect, which helps to improve skin texture and smoothness. By reinforcing the skin barrier, it prevents transepidermal water loss (TEWL), ensuring the delicate under-eye area remains hydrated.

Additionally, it possesses anti-inflammatory properties that reduce oxidative stress and prevent skin irritation, making it suitable for sensitive skin. By suppressing the release of pro-inflammatory cytokines, Acetyl Tetrapeptide-5 helps counteract redness and puffiness caused by fatigue, stress, or environmental factors.

Future Research and Applications
While Acetyl Tetrapeptide-5 is primarily used in eye care formulations, researchers are exploring its potential applications in full-face anti-aging treatments to improve skin firmness and hydration. New formulations combining this peptide with hyaluronic acid, niacinamide, and caffeine have shown promising results in boosting its efficacy for skin rejuvenation.

With its scientifically backed ability to reduce puffiness, prevent collagen degradation, and enhance skin hydration, Acetyl Tetrapeptide-5 continues to be a cornerstone ingredient in modern skincare, particularly in eye treatment formulations targeting dark circles and tired-looking eyes.

Reference:

Wyrzykowski, D., Kloska, A., Zdrowowicz, M., Wieczorek, R., & Makowska, J. (2022). Modification of amino-acid sequence of cosmetic peptide Eyeseryl enhances the affinity towards copper (II) ion. Polyhedron, 222, 115948.