Product Name: Hexapeptide-11
Cas No: 161258-30-6
Purity: 98%
Form: Acetate Salt
Chemical Formula: C36H48N6O7
Molar Mass: 676.82
Synonyms: Fvapfp; Peptamide 6; Phe-val-ala-pro-phe-pro
IUPAC Name: (2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carboxylic acid
SMILES: CC@@HNC@@HC(=O)N3CCC[C@H]3C(=O)O)NC(=O)C@HNC(=O)C@HN
InChIKey: GFEYWOGCSROPRT-OBXVVNIGSA-N
InChI: InChI=1S/C36H48N6O7/c1-22(2)30(40-31(43)26(37)20-24-12-6-4-7-13-24)33(45)38-23(3)34(46)41-18-10-16-28(41)32(44)39-27(21-25-14-8-5-9-15-25)35(47)42-19-11-17-29(42)36(48)49/h4-9,12-15,22-23,26-30H,10-11,16-21,37H2,1-3H3,(H,38,45)(H,39,44)(H,40,43)(H,48,49)/t23-,26-,27-,28-,29-,30-/m0/s1
Storage: -20 degree Celsius
Sequence: FVAPFP
Application:
Hexapeptide-11 (FVAPFP) is a naturally inspired bioactive peptide known for its ability to support skin firmness and elasticity. This hexamer has been shown to enhance cellular metabolism, promoting improved collagen and elastin expression for smoother, more resilient skin. Its gentle activity makes it ideal for anti-aging formulations targeting early signs of sagging, dullness, and texture changes. Hexapeptide-11 is widely used in serums, essences, and daily moisturizers where lightweight, biomimetic actives are preferred. Its compatibility with botanical-based and clean-beauty formulations also makes it a popular choice for modern skincare brands seeking high-performance peptide technology.
Current Research:
Hexapeptide-11 (FVAPFP) – Current Research Overview
Hexapeptide-11 is a bioactive cosmetic peptide originally discovered in yeast fermentation extracts and later produced by synthetic and biotechnological methods for consistent purity. Its sequence—Phe-Val-Ala-Pro-Phe-Pro (FVAPFP)—belongs to a family of small peptides known for their ability to influence cellular metabolism, proteostasis, and extracellular matrix (ECM) homeostasis. Current research highlights Hexapeptide-11 as a multi-target anti-aging ingredient with activity spanning stress resistance, protein quality control, remodeling of dermal components, and improvements in skin elasticity.
Hexapeptide-11 was identified after observations that workers in fermentation facilities often exhibited unusually smooth and firm skin. Subsequent analysis revealed that peptides released during yeast fermentation contributed to enhanced skin qualities. Hexapeptide-11 was isolated as one of the most active components and later synthesized to achieve standardized cosmetic-grade material. Recent developments have also explored fermentation-based production, where engineered yeast biosynthesize the peptide directly, aligning with clean-beauty and biotechnology-driven ingredient trends.
One of the most significant areas of research focuses on the peptide’s role in proteostasis maintenance, an essential mechanism for healthy cellular function. Studies on human fibroblasts show that Hexapeptide-11 can upregulate key genes associated with the proteasome, autophagy, molecular chaperones, and antioxidant enzymes. This coordinated gene activation enhances the cell’s ability to clear damaged proteins, reduce oxidative burden, and resist stress-induced premature senescence. Importantly, the peptide increases nuclear accumulation of Nrf2, a master regulator of antioxidant defense, suggesting that Hexapeptide-11 strengthens the skin’s resilience to environmental damage.
The proteostasis-centered mechanism is especially relevant for aging skin, where declining protein turnover contributes to dullness, laxity, and increased wrinkle formation. By supporting cellular detoxification and defense pathways, Hexapeptide-11 helps maintain a more youthful cellular state.
Research also highlights the peptide’s influence on the extracellular matrix, which determines skin firmness and support. In vitro data indicate that Hexapeptide-11 can enhance the expression of collagen, elastin, and other matrix components. Interestingly, it has a dual effect on matrix metalloproteinases (MMPs): it can promote controlled MMP activity while also reducing cell migration. This controlled remodeling response supports renewal of damaged ECM structures without excessive degradation.
Human studies using biomechanical measurements, such as cutometer elasticity testing, have shown that topical application of Hexapeptide-11 improves key parameters linked to skin firmness and recoil. These findings align with its molecular activity and support its use in firming and anti-aging skincare formulations.
Consumer and small-scale clinical evaluations describe gradual improvements in skin texture, radiance, and the appearance of fine lines. While these studies vary in rigor, the reported benefits include smoother skin surfaces, reduced visibility of wrinkles, and enhanced overall tone. Researchers attribute these improvements to the peptide’s combined effects on antioxidant response, ECM renewal, and improved cellular vitality.
Beyond skin, preliminary cosmetic science discussions propose that Hexapeptide-11 may influence hair biology. Some findings suggest potential modulation of androgen-related gene expression and support for hair follicle metabolism. While research in this area is still developing, the peptide shows promise for future hair-thickening, scalp-refreshing, or anti-aging scalp formulations.
Recent work also explores advanced delivery systems and modified derivatives of Hexapeptide-11 designed to enhance penetration, stability, and potency. Researchers have described analogs with optimized lipophilicity and peptide–lipid conjugates that increase skin absorption without increasing irritation. Formulation science increasingly pairs Hexapeptide-11 with liposomes, bio-fermented complexes, or microemulsions to maximize bioavailability, indicating growing interest in strengthening its performance profile.
Current research positions Hexapeptide-11 as a versatile, biomimetic cosmetic peptide capable of improving skin firmness, resilience, and overall quality through a multi-pathway approach. Its actions on proteostasis, antioxidant defense, ECM support, and cellular longevity make it particularly valuable in modern formulations targeting visible aging, environmental stress, and preventive “prejuvenation” concepts.
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