Product Name:Lipopeptide
Form:TFA Salt
Purity:97%
Storage:2-8 degree Celsius
Cas No:171263-26-6
Molar Mass:736.98
Chemical Formula:C38H68N6O8
Synonyms:Palmitoyl Hexapeptide
IUPAC Name:2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-(hexadecanoylamino)-3-methylbutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetic acid
SMILES:CCCCCCCCCCCCCCCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
InChIKey:JFSQSDAOQLNSQI-DTBJPNGVSA-N
InChI:InChI=1S/C38H68N6O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-22-30(45)42-33(26(2)3)36(50)39-24-31(46)43-34(27(4)5)37(51)41-28(6)38(52)44-23-20-21-29(44)35(49)40-25-32(47)48/h26-29,33-34H,7-25H2,1-6H3,(H,39,50)(H,40,49)(H,41,51)(H,42,45)(H,43,46)(H,47,48)/t28-,29-,33-,34-/m0/s1
Sequence:Palm-Val-Gly-Val-Ala-Pro-Gly
Application:
Palmitoyl Hexapeptide is a bioactive lipopeptide renowned for its anti-aging properties. This synthetic compound combines a hexapeptide sequence—Val-Gly-Val-Ala-Pro-Gly—with palmitic acid, enhancing its skin penetration and stability. By mimicking fragments of elastin, it stimulates the production of collagen, elastin, fibronectin, and glycosaminoglycans, essential components for maintaining skin's structural integrity. Regular application leads to improved skin elasticity, reduced appearance of fine lines and wrinkles, and enhanced hydration. Palmitoyl Hexapeptide-12 is widely incorporated into anti-aging creams, serums, and lotions, offering a non-invasive solution to combat visible signs of aging and promote a youthful complexion.
Current Research:
Palmitoyl Hexapeptide, also known as Biopeptide-EL, has garnered significant attention in dermatological research for its potential in skin rejuvenation and anti-aging. This synthetic lipopeptide merges a specific hexapeptide sequence with palmitic acid, facilitating better skin absorption and enhanced bioavailability.
Mechanism of Action: Stimulation of Extracellular Matrix Components
The hexapeptide sequence in Palmitoyl Hexapeptide closely resembles fragments of elastin, a key protein in the skin's extracellular matrix (ECM). This structural similarity enables it to:
Stimulate Fibroblast Activity: Encourages fibroblasts to produce essential ECM components, including collagen, elastin, and fibronectin, which are vital for skin firmness and elasticity.
Enhance Glycosaminoglycan Production: Promotes the synthesis of glycosaminoglycans, such as hyaluronic acid, improving skin hydration and volume.
Collectively, these actions contribute to a more resilient and youthful skin appearance.
Clinical Studies and Efficacy
Several studies have investigated the efficacy of Palmitoyl Hexapeptid:
Collagen and Elastin Stimulation: Research indicates that this peptide specifically targets elastin molecules, stimulating collagen and elastin fibroblasts, as well as promoting the development of glycosaminoglycans and fibronectin.
Angiogenesis Promotion: In vivo studies using chick chorioallantoic membrane models have demonstrated that Palmitoyl Hexapeptide-12 enhances angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of membrane-type metalloproteinase-1 (MT1-MMP), a matrix metalloproteinase.
Anti-Inflammatory Properties: This peptide has been shown to reduce the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6), by keratinocytes and fibroblasts. Elevated levels of IL-6 are associated with skin aging and inflammatory responses, suggesting that Palmitoyl Hexapeptide-12 may help mitigate these effects.
Comparison with Other Peptides
Palmitoyl Hexapeptide is often compared to other peptides like Palmitoyl Pentapeptide-4 (Matrixyl) and Palmitoyl Tripeptide-1. While all these peptides aim to stimulate collagen production, Palmitoyl Hexapeptide-12 uniquely mimics elastin fragments, providing targeted stimulation of elastin and collagen synthesis. This specificity may result in more pronounced improvements in skin elasticity and firmness.
Future Research and Applications
Ongoing research is exploring the broader applications of Palmitoyl Hexapeptide:
Wound Healing: Its ability to promote angiogenesis and ECM production positions it as a potential agent in enhancing wound healing processes.
Combination Therapies: Investigating synergistic effects when combined with other peptides or active ingredients could lead to more effective anti-aging formulations.
Delivery Systems: Developing advanced delivery mechanisms, such as encapsulation in liposomes or nanoparticles, may further enhance its stability and penetration, maximizing therapeutic outcomes.
In conclusion, Palmitoyl Hexapeptide stands as a promising ingredient in cosmetic and dermatological applications, offering multifaceted benefits in skin rejuvenation and anti-aging. Continued research and development are likely to expand its applications and efficacy in skincare formulations.
Reference:
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