Palmitoyl Tetrapeptide-7

Product Name:Palmitoyl Tetrapeptide-7

Form:TFA Salt

Purity:98%

Storage:2-8 degree Celsius

Cas No:221227-05-0

Molar Mass:694.91

Chemical Formula:C34H62N8O7

IUPAC Name:(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[2-(hexadecanoylamino)acetyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid

SMILES:CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O

InChIKey:IHRKJQSLKLYWBQ-QKDODKLFSA-N

InChI:InChI=1S/C34H62N8O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-29(44)39-24-30(45)40-25(20-21-28(35)43)32(47)42-23-16-18-27(42)31(46)41-26(33(48)49)17-15-22-38-34(36)37/h25-27H,2-24H2,1H3,(H2,35,43)(H,39,44)(H,40,45)(H,41,46)(H,48,49)(H4,36,37,38)/t25-,26-,27-/m0/s1

Sequence:Palm-Gly-Gln-Pro-Arg

Application:

Palmitoyl Tetrapeptide-7 is an advanced anti-inflammatory and anti-aging peptide known for its ability to reduce skin irritation, improve elasticity, and minimize fine lines and wrinkles. It works by inhibiting pro-inflammatory cytokines, particularly interleukin-6 (IL-6), which contributes to skin aging and collagen degradation. Additionally, this peptide enhances skin repair and regeneration, promoting a smoother, firmer complexion. Palmitoyl Tetrapeptide-7 is often combined with Palmitoyl Oligopeptide (Matrixyl 3000®) in anti-aging serums, moisturizers, and eye creams to improve skin resilience, hydration, and overall texture. Its ability to reduce inflammation and oxidative stress makes it a key ingredient in skincare targeting redness, wrinkles, and environmental damage.

Current Research:

Palmitoyl Tetrapeptide-7 is a synthetic tetrapeptide extensively studied for its role in reducing inflammation, enhancing skin repair, and preventing collagen breakdown. It is widely used in anti-aging and sensitive skin formulations due to its ability to inhibit inflammatory responses and oxidative stress, two major contributors to premature skin aging.

Mechanism of Action: Anti-Inflammatory and Anti-Aging Effects
Palmitoyl Tetrapeptide-7 primarily works by modulating cytokine production, specifically:

Inhibiting interleukin-6 (IL-6) – a pro-inflammatory cytokine that increases with age and contributes to collagen degradation, hyperpigmentation, and skin sensitivity.
Reducing oxidative stress – lowering free radical damage, which accelerates wrinkle formation and skin aging.
Enhancing extracellular matrix integrity – promoting the synthesis of collagen and elastin, leading to improved skin firmness and elasticity.
A study published in the International Journal of Cosmetic Science found that Palmitoyl Tetrapeptide-7, when combined with Palmitoyl Oligopeptide (Matrixyl 3000®), increased collagen production by up to 33%, leading to improved skin texture, elasticity, and hydration.

Clinical Studies and Efficacy
Multiple studies have demonstrated the effectiveness of Palmitoyl Tetrapeptide-7 in reducing visible signs of aging and improving skin health:

A clinical trial on Matrixyl 3000® (a combination of Palmitoyl Tetrapeptide-7 and Palmitoyl Oligopeptide) found that wrinkle depth decreased by 45% after two months, with skin roughness improving by 20%.
Another study showed that Palmitoyl Tetrapeptide-7 reduced UV-induced inflammation by lowering IL-6 levels, making it beneficial for sun-damaged and sensitive skin.
Comparison with Other Anti-Aging Peptides
Palmitoyl Tetrapeptide-7 is often compared to other peptides like Argireline (Acetyl Hexapeptide-8) and Palmitoyl Tripeptide-5. While Argireline focuses on reducing muscle contractions to prevent dynamic wrinkles, Palmitoyl Tetrapeptide-7 works by repairing and strengthening skin from within, making it ideal for mature and sensitive skin types.

Compared to collagen-boosting peptides like Matrixyl® (Palmitoyl Pentapeptide-4), Palmitoyl Tetrapeptide-7 has an added anti-inflammatory benefit, helping to reduce redness and irritation along with improving skin elasticity and hydration.

Future Research and Applications
Ongoing studies are examining Palmitoyl Tetrapeptide-7 in combination with antioxidants, ceramides, and growth factors to enhance its anti-aging and skin-repairing effects. Researchers are also investigating its role in post-inflammatory hyperpigmentation (PIH) reduction and skin barrier strengthening.

With its clinically proven ability to reduce inflammation, improve collagen synthesis, and enhance skin hydration, Palmitoyl Tetrapeptide-7 is a key ingredient in modern anti-aging and sensitive skincare formulations, particularly in moisturizers, serums, and eye creams targeting wrinkles, redness, and environmental damage.

Reference:

Johnson Jr, W., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Heldreth, B. (2018). Safety assessment of tripeptide-1, hexapeptide-12, their metal salts and fatty acyl derivatives, and palmitoyl tetrapeptide-7 as used in cosmetics. International journal of toxicology, 37(3_suppl), 90S-102S.