Nonapeptide-1

Product Name:Nonapeptide-1

CAS No:158563-45-2

Purity:95%

Molar Mass:1206.5

Chemical Formula:C61H87N15O9S

Storage:Store at -20 degrees Celsius

Sequence:MPFRWFKPV-NH2

Target:MC1R

Application:Nonapeptide-1 is a synthetic peptide primarily used in skincare for its skin-brightening and anti-pigmentation properties. It works by inhibiting the activity of tyrosinase, an enzyme involved in melanin production, which helps reduce hyperpigmentation, dark spots, and uneven skin tone. Nonapeptide-1 is a key ingredient in many cosmetic products aimed at achieving a lighter complexion or addressing conditions such as melasma and age spots. Its gentle mechanism of action makes it a popular choice in formulations for sensitive skin, offering an alternative to harsher depigmentation agents like hydroquinone.

Current Research:

Nonapeptide-1, also known as Melanostatine-5, is a synthetic peptide composed of nine amino acids. It functions as a competitive antagonist to ??-melanocyte-stimulating hormone (??-MSH) by binding to melanocortin 1 receptors (MC1R) on melanocytes, thereby inhibiting melanin synthesis. Mechanism of Action By competitively binding to MC1R, Nonapeptide-1 prevents ??-MSH from activating the receptor. This inhibition reduces intracellular cyclic adenosine monophosphate (cAMP) levels, leading to decreased activity of tyrosinase, the key enzyme in melanin production. Consequently, melanin synthesis is reduced, resulting in a lighter skin tone and diminished hyperpigmentation. Applications in Skincare Due to its ability to modulate melanin production, Nonapeptide-1 is incorporated into various cosmetic formulations aimed at skin brightening and the treatment of hyperpigmentation disorders such as melasma and age spots. Its targeted action offers a gentler alternative to traditional depigmenting agents, minimizing potential side effects. Safety Profile Nonapeptide-1 has been evaluated for safety in cosmetic applications. Studies indicate that it is generally well-tolerated when used within recommended concentrations. However, as with any active ingredient, it is advisable to conduct patch testing to ensure individual compatibility. Conclusion Nonapeptide-1 serves as an effective agent in skin care for reducing hyperpigmentation and promoting a more even skin tone. Its specific mechanism of action allows for targeted treatment, making it a valuable component in cosmetic formulations addressing pigmentation concerns.

Reference:

Chatterjee, M., Neema, S., & Rajput, G. R. (2021). A randomized controlled pilot study of a proprietary combination versus sunscreen in melasma maintenance. Indian Journal of Dermatology, Venereology and Leprology, 88(1), 51-58.