Acetyl Tetrapeptide-3

Product Name:Acetyl Tetrapeptide-3

Form:TFA Salt

Purity:98%

Storage:2-8 degree Celsius

Cas No:827306-88-7

Molar Mass:468.5

Chemical Formula:C22H39N9O5

Synonyms:827306-88-7; Folixyl; Kollaren 6

IUPAC Name:(2S)-2-[[(2S)-2-[[2-[[(2S)-2-acetamido-6-aminohexanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanamide

SMILES:CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)N

InChIKey:RRJOMESUBQAYOA-BZSNNMDCSA-N

InChI:InChI=1S/C22H39N9O5/c1-14(32)29-17(7-3-5-9-24)21(35)27-12-19(33)30-18(10-15-11-26-13-28-15)22(36)31-16(20(25)34)6-2-4-8-23/h11,13,16-18H,2-10,12,23-24H2,1H3,(H2,25,34)(H,26,28)(H,27,35)(H,29,32)(H,30,33)(H,31,36)/t16-,17-,18-/m0/s1

Sequence:Ac-Lys-Gly-His-Lys

Application:

Acetyl Tetrapeptide-3 is a bioactive peptide known for its ability to enhance hair follicle strength and promote hair growth. It works by stimulating extracellular matrix protein synthesis, including collagen and laminin, which fortify the dermal papilla and improve follicle anchoring. This peptide is commonly used in anti-hair loss treatments and scalp care products, as it helps prolong the anagen (growth) phase while reducing follicle miniaturization. Additionally, Acetyl Tetrapeptide-3 has anti-inflammatory properties, making it beneficial for maintaining scalp health. Frequently combined with red clover extract, it is a key ingredient in hair-thickening serums, eyelash enhancers, and anti-aging scalp therapies.

Current Research:

Acetyl Tetrapeptide-3 has gained significant recognition in dermatological and cosmetic research for its role in stimulating hair growth and maintaining scalp health. As a synthetic peptide designed to enhance the structural integrity of hair follicles, it has been studied for its effects on dermal papilla cells, the primary regulators of hair follicle function.

Mechanism of Action in Hair Growth
Acetyl Tetrapeptide-3 primarily works by increasing the expression of key extracellular matrix (ECM) proteins such as collagen VII, laminin-5, and fibronectin, which are essential for strengthening the dermal-epidermal junction. By reinforcing follicle anchoring, it helps reduce hair shedding and improves the overall density of hair.

Additionally, Acetyl Tetrapeptide-3 has been shown to modulate the hair cycle by prolonging the anagen (growth) phase while shortening the telogen (resting) phase, leading to increased hair retention. This effect is attributed to its ability to enhance fibroblast activity and stimulate dermal papilla cells, which are responsible for hair follicle regeneration.

A 2012 study published in the Journal of Applied Cosmetology demonstrated that a topical formula containing Acetyl Tetrapeptide-3, in combination with red clover extract (rich in biochanin A), significantly improved hair follicle strength and reduced hair loss over a 4-month period. The study highlighted its potential as a non-invasive alternative for individuals experiencing early-stage hair thinning.

Scalp Health and Anti-Inflammatory Properties
Chronic inflammation is a contributing factor to hair loss, particularly in conditions such as androgenetic alopecia and alopecia areata. Acetyl Tetrapeptide-3 has demonstrated anti-inflammatory effects by modulating cytokine activity and reducing oxidative stress on the scalp. By inhibiting pro-inflammatory markers such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), this peptide helps maintain a balanced scalp environment, which is essential for healthy hair growth.

Furthermore, it enhances microcirculation in the scalp, promoting better nutrient delivery to hair follicles. This makes Acetyl Tetrapeptide-3 a valuable ingredient in advanced hair care formulations targeting scalp revitalization.

Future Research and Applications
Ongoing studies aim to further optimize the bioavailability and efficacy of Acetyl Tetrapeptide-3 in hair regrowth treatments. Researchers are investigating its potential in combination with other bioactive peptides, stem cell activators, and nanocarrier systems to improve its penetration into the scalp.

As the demand for non-invasive hair restoration solutions grows, Acetyl Tetrapeptide-3 remains a promising candidate for future cosmeceutical innovations. Its ability to strengthen hair follicles, reduce inflammation, and support scalp health solidifies its position as a key component in hair rejuvenation therapies.

Reference:

Lueangarun, S., & Panchaprateep, R. (2020). An herbal extract combination (biochanin A, Acetyl tetrapeptide-3, and Ginseng extracts) versus 3% minoxidil solution for the treatment of androgenetic alopecia: a 24-week, prospective, randomized, triple-blind, controlled trial. The Journal of clinical and aesthetic dermatology, 13(10), 32.