Product Name: Myristoyl Hexapeptide-16
Cas No: 959610‑54‑9
Purity: 98%
Chemical Formula: C47H91N9O8
Molar Mass: 910.3
Synonyms: HY-P5235; DA-55800
IUPAC Name: (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-4-methyl-2-(tetradecanoylamino)pentanoyl]amino]hexanoyl]amino]hexanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid
SMILES: CCCCCCCCCCCCCC(=O)NC@@HC(=O)NC@@HC(=O)NC@@HC(=O)NC@@HC(=O)NC@@HC(=O)NC@@HC(=O)O
InChIKey: CXJWENHUGAZQFI-UNHORJANSA-N
InChI: InChI=1S/C47H91N9O8/c1-7-8-9-10-11-12-13-14-15-16-17-27-41(57)52-39(31-33(2)3)45(61)54-37(25-19-22-29-49)44(60)53-36(24-18-21-28-48)43(59)51-35(6)42(58)56-40(32-34(4)5)46(62)55-38(47(63)64)26-20-23-30-50/h33-40H,7-32,48-50H2,1-6H3,(H,51,59)(H,52,57)(H,53,60)(H,54,61)(H,55,62)(H,56,58)(H,63,64)/t35-,36-,37-,38-,39-,40-/m0/s1
Storage: -4 degree Celsius
Sequence: LKKALK
Application:
Myristoyl Hexapeptide-16 is a bioengineered lipopeptide that combines a myristoyl fatty acid chain with a synthetic hexapeptide sequence to enhance skin penetration and cellular communication. It mimics natural growth factors involved in skin regeneration, promoting increased collagen and elastin synthesis. This peptide is particularly effective in anti-aging formulations, contributing to improved skin firmness, texture, and hydration. Its amphiphilic structure allows superior dermal absorption, making it ideal for cosmetic applications targeting fine lines, sagging, and roughness. Stable and potent at low concentrations, Myristoyl Hexapeptide-16 is a valuable active ingredient for innovative skincare formulations and advanced cosmeceutical research.
Current Research:
Application Overview
- Anti-Aging and Skin Firmness
Myristoyl Hexapeptide-16 plays a critical role in modern anti-aging skincare formulations. By stimulating collagen and elastin production, it helps restore skin structure, firmness, and elasticity. The hexapeptide sequence mimics portions of natural proteins involved in extracellular matrix signaling, effectively "tricking" skin cells into behaving more youthfully. This can visibly reduce the appearance of fine lines, sagging, and crepey texture over consistent use. Unlike traditional retinoids, which may cause irritation or peeling, Myristoyl Hexapeptide-16 offers a gentler yet effective alternative suitable for sensitive skin types.
- Enhanced Penetration through Myristoylation
The myristoyl group (a 14-carbon fatty acid chain) confers lipophilicity to the peptide, greatly enhancing its ability to penetrate the skin’s lipid barrier. This feature ensures that the peptide reaches the deeper dermal layers where fibroblasts reside—cells essential for the production of collagen, elastin, and hyaluronic acid. Such targeted delivery increases the bioavailability of the peptide and ensures more potent results at lower concentrations. Formulators can thereby create cost-effective, high-performance products that meet growing consumer demand for visible anti-aging benefits with minimal irritation.
- Skin Renewal and Texture Improvement
In addition to firming and wrinkle reduction, Myristoyl Hexapeptide-16 encourages cellular regeneration, leading to smoother skin texture and improved overall tone. It is particularly useful in formulations intended to support post-acne healing, photoaged skin, or mature complexions experiencing a loss of skin density. With consistent use, it can help diminish uneven patches and promote a more luminous, youthful appearance. Its regenerative effects also make it compatible with exfoliating agents like AHAs and BHAs, providing a complementary recovery mechanism for skin undergoing regular resurfacing treatments.
- Compatibility with Other Actives
Myristoyl Hexapeptide-16 demonstrates excellent stability and is compatible with a wide range of cosmetic ingredients, including niacinamide, ceramides, peptides like Matrixyl® or Argireline®, and even encapsulated retinoids. Its ability to synergize with other actives enables the design of comprehensive anti-aging serums or creams that address multiple signs of skin aging—firmness, hydration, discoloration, and textural irregularities—in one formula. It can also be incorporated into liposomal or nanocarrier systems to further enhance targeted delivery and efficacy.
- Usage in Formulation
Recommended concentration levels for Myristoyl Hexapeptide-16 in topical products range from 0.5% to 2%, depending on the formulation goals. It can be introduced during the cooling phase of emulsification processes to preserve its integrity. Common delivery formats include serums, moisturizers, eye creams, and ampoules. For advanced cosmetic treatments, it may also be utilized in conjunction with microneedle patches or facial masks for intensive skin recovery regimens.
Reference:
Sachdev, M., Velugotla, K., Revanker, S., & Somasekhar, G. (2020). An open-label, single-center, safety and efficacy study of eyelash polygrowth factor serum. The Journal of clinical and aesthetic dermatology, 13(2), 61.
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