Matrixyl 3000

Product Name:Matrixyl 3000

Form:HCI Salt

Purity:98%

Storage:2-8 degree Celsius

Cas No:147732-56-7 : 221227-05-0 (2:1)

Molar Mass:578.8

Chemical Formula:C30H54N6O5

Synonyms:Palmitoyl Tripeptide-1, Pal-GHK

IUPAC Name:(2S)-6-amino-2-[[(2S)-2-[[2-(hexadecanoylamino)acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid

SMILES:CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)O

InChIKey:BYUQATUKPXLFLZ-UIOOFZCWSA-N

InChI:InChI=1S/C30H54N6O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18-27(37)33-22-28(38)35-26(20-24-21-32-23-34-24)29(39)36-25(30(40)41)17-15-16-19-31/h21,23,25-26H,2-20,22,31H2,1H3,(H,32,34)(H,33,37)(H,35,38)(H,36,39)(H,40,41)/t25-,26-/m0/s1

Sequence:Palm-Gly-His-Lys

Application:

Matrixyl® 3000 is a powerful anti-aging peptide complex composed of Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7, designed to stimulate collagen production, improve skin elasticity, and reduce wrinkles. It works by activating extracellular matrix renewal and repairing damaged skin proteins, leading to smoother, firmer, and younger-looking skin. Clinical studies have demonstrated that Matrixyl® 3000 can reduce wrinkle depth by up to 45% and improve skin elasticity by 20% within weeks of use. This peptide is widely used in anti-aging serums, creams, and eye treatments, offering an effective solution for wrinkle reduction, hydration, and long-term skin rejuvenation.

Current Research:

Matrixyl® 3000 is a next-generation peptide complex widely studied for its ability to counteract the visible signs of aging by promoting collagen synthesis and reducing inflammation. As a combination of Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7, it works synergistically to repair and strengthen the skin’s extracellular matrix (ECM), making it a key ingredient in high-performance anti-aging skincare formulations.

Mechanism of Action: Collagen Synthesis and Skin Repair
Aging leads to the degradation of collagen, elastin, and hyaluronic acid, resulting in wrinkles, sagging, and loss of skin elasticity. Matrixyl® 3000 counteracts this process through:

Palmitoyl Tripeptide-1 – Functions as a messenger peptide, mimicking the body’s natural collagen breakdown fragments to stimulate fibroblast activity and increase the production of collagen and elastin.
Palmitoyl Tetrapeptide-7 – Reduces inflammation and oxidative stress by inhibiting interleukin-6 (IL-6), a cytokine responsible for collagen degradation and premature skin aging.
Together, these peptides restore skin integrity, improve hydration, and promote firmness, leading to a visible reduction in fine lines and wrinkles.

Clinical Studies and Efficacy
Several clinical and in vitro studies have validated the anti-aging benefits of Matrixyl® 3000:

Reduction in Wrinkle Depth – A 12-week clinical study demonstrated that Matrixyl® 3000 reduced wrinkle depth by up to 45%, with a noticeable improvement in skin smoothness and elasticity.
Enhanced Skin Hydration and Firmness – Participants using a 5% Matrixyl® 3000 formulation reported a 20% increase in skin elasticity and hydration, making the skin appear more youthful and plump.
Long-Term Skin Regeneration – Continuous application was found to accelerate skin renewal and reinforce the skin barrier, leading to firmer, healthier-looking skin over time.
Comparison with Other Anti-Aging Peptides
Matrixyl® 3000 is often compared to other collagen-boosting peptides, such as Matrixyl® (Palmitoyl Pentapeptide-4) and Palmitoyl Tripeptide-5. Unlike its predecessors, Matrixyl® 3000 offers both collagen stimulation and anti-inflammatory benefits, making it more effective for mature and sensitive skin types.

Additionally, it differs from Argireline (Acetyl Hexapeptide-8), which reduces muscle contractions to prevent dynamic wrinkles. Instead, Matrixyl® 3000 targets structural wrinkles and collagen loss, making it ideal for firming and repairing aging skin.

Future Research and Applications
Ongoing studies are exploring Matrixyl® 3000 in combination with hyaluronic acid, niacinamide, and antioxidants to further enhance skin hydration, firmness, and repair. Researchers are also investigating its potential in wound healing and post-inflammatory skin recovery.

With its proven ability to reduce wrinkles, improve skin elasticity, and promote long-term rejuvenation, Matrixyl® 3000 remains one of the most effective peptides in anti-aging skincare, particularly in serums, creams, and eye treatments targeting mature and aging skin.

Reference:

Tałałaj, U., Uścinowicz, P., Bruzgo, I., Surażyński, A., Zaręba, I., & Markowska, A. (2019). The effects of a novel series of KTTKS analogues on cytotoxicity and proteolytic activity. Molecules, 24(20), 3698.