Palmitoyl Tripeptide-5

Product Name:Palmitoyl Tripeptide-5

Form:TFA Salt

Purity:98%

Storage:2-8 degree Celsius

Cas No:623172-56-5

Molar Mass:611.9

Chemical Formula:C33H65N5O5

IUPAC Name:(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid;2,2,2-trifluoroacetic acid

SMILES:CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

InChIKey:FKCOHLNFINRFFR-RROPMPDHSA-N

InChI:InChI=1S/C33H65N5O5.2C2HF3O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-23-29(39)36-27(21-17-19-24-34)31(40)38-30(26(2)3)32(41)37-28(33(42)43)22-18-20-25-35;2*3-2(4,5)1(6)7/h26-28,30H,4-25,34-35H2,1-3H3,(H,36,39)(H,37,41)(H,38,40)(H,42,43);2*(H,6,7)/t27-,28-,30-;;/m0../s1

Sequence:KVK

Application:

Palmitoyl Tripeptide-5 is an advanced collagen-boosting peptide designed to improve skin firmness, elasticity, and overall smoothness. It works by stimulating collagen synthesis and inhibiting matrix metalloproteinases (MMPs), which break down collagen over time. This peptide also enhances cell communication to support skin repair and rejuvenation. Clinical studies have shown that Palmitoyl Tripeptide-5 can visibly reduce wrinkles, fine lines, and sagging skin, making it a key ingredient in anti-aging serums, creams, and eye treatments. Its ability to penetrate deep into the skin and promote structural integrity makes it highly effective in restoring a youthful, firm, and plump complexion.

Current Research:

Palmitoyl Tripeptide-5 is a bioactive peptide extensively researched for its role in collagen synthesis, skin regeneration, and anti-aging applications. Unlike some peptides that only work on the skin’s surface, Palmitoyl Tripeptide-5 can penetrate deeper layers to interact with fibroblast cells, triggering collagen production at the source.

Mechanism of Action in Collagen Production
Collagen degradation is a primary factor in skin aging, leading to wrinkles, loss of firmness, and sagging skin. Palmitoyl Tripeptide-5 counteracts this process by:

Stimulating TGF-β (Transforming Growth Factor Beta), a key regulator of collagen production in fibroblasts.
Inhibiting matrix metalloproteinases (MMPs), which break down collagen and accelerate skin aging.
Enhancing skin cell communication, promoting tissue repair and overall structural integrity.
A clinical study published in the International Journal of Cosmetic Science found that Palmitoyl Tripeptide-5 can increase collagen synthesis by over 75% when applied consistently. This leads to improved skin elasticity, reduced fine lines, and enhanced dermal density.

Anti-Wrinkle and Skin Firming Effects
Multiple in vitro and in vivo studies have demonstrated the effectiveness of Palmitoyl Tripeptide-5 in reducing wrinkle depth and improving skin firmness:

A 12-week clinical trial involving participants using a Palmitoyl Tripeptide-5-infused serum showed a significant reduction in wrinkle depth (up to 35%) and an increase in skin elasticity by 20%.
The peptide also helps improve skin hydration and smoothness, contributing to a plumper and more youthful complexion.
Comparison with Other Peptides
Palmitoyl Tripeptide-5 is often compared to Matrixyl® (Palmitoyl Pentapeptide-4), another collagen-boosting peptide. While both peptides target collagen regeneration, Palmitoyl Tripeptide-5 has deeper penetration and directly interacts with fibroblasts, making it more effective for firming and long-term anti-aging benefits.

Additionally, unlike Argireline (Acetyl Hexapeptide-8), which reduces muscle contractions to prevent expression wrinkles, Palmitoyl Tripeptide-5 works by strengthening skin structure and repairing collagen damage rather than relaxing facial muscles.

Future Research and Applications
Ongoing research is investigating the combination of Palmitoyl Tripeptide-5 with hyaluronic acid, vitamin C, and other growth factors to enhance its collagen-boosting and skin-repairing properties. Scientists are also exploring its potential applications in wound healing and scar reduction.

With its proven ability to boost collagen, improve skin elasticity, and reduce wrinkles, Palmitoyl Tripeptide-5 is a leading ingredient in high-performance anti-aging skincare, particularly in firming serums, anti-wrinkle creams, and regenerative treatments.

Reference:

Ngoc, L. T. N., Moon, J. Y., & Lee, Y. C. (2023). Insights into bioactive peptides in cosmetics. Cosmetics, 10(4), 111.