LEP (116-130) (mouse)

Product Name:LEP (116-130) (mouse)

CAS No:258276-95-8

Purity:95%

Molar Mass:1560.73

Chemical Formula:C64H109N19O24S

Storage:Store at -20 degrees Celsius

Sequence:SCSLPQTSGLQKPES

Application:

LEP (116-130) (mouse) is a synthetic peptide fragment derived from leptin, a hormone crucial for regulating energy balance, appetite, and metabolism. This specific fragment, corresponding to amino acids 116-130, retains some of leptin's biological activity and is used in research to study the role of leptin signaling, particularly its effects on weight regulation, metabolism, and insulin sensitivity. LEP (116-130) provides insights into how specific regions of the leptin molecule contribute to its physiological actions, aiding in the exploration of therapeutic strategies for obesity, metabolic disorders, and related diseases in studies using mouse models.

Current Research:

Leptin, a hormone predominantly secreted by adipocytes, plays a pivotal role in regulating energy balance, appetite, and metabolism. The leptin peptide fragment encompassing amino acids 116 to 130, referred to as LEP (116-130), has been synthesized to investigate its biological activities, particularly in murine models.
Biological Activity
LEP (116-130) has demonstrated significant effects on body weight regulation and glucose metabolism in mice:
Body Weight and Food Intake: Administration of LEP (116-130) at a dose of 1 mg intraperitoneally in mice resulted in a reduced rate of body weight gain, despite an increase in food intake compared to vehicle-injected control mice.
Glucose Levels: The same treatment significantly decreased blood glucose levels by approximately 100 mg/dL, indicating a potential role in glucose homeostasis.
Mechanism of Action
The precise mechanisms through which LEP (116-130) exerts its effects remain under investigation. It is hypothesized that this peptide fragment may interact with leptin receptors or other components of the leptin signaling pathway, thereby influencing metabolic processes. However, further research is necessary to elucidate these pathways and confirm the specific interactions involved.
Research Applications
Due to its impact on body weight and glucose regulation, LEP (116-130) serves as a valuable tool in metabolic research:
Obesity Studies: By modulating weight gain and food intake, LEP (116-130) provides insights into the mechanisms of obesity and potential therapeutic targets.
Diabetes Research: Its ability to lower blood glucose levels makes it relevant in the study of diabetes and related metabolic disorders.
Conclusion
LEP (116-130) (mouse) is a synthetic leptin peptide fragment that has shown promising effects in reducing body weight gain and lowering blood glucose levels in murine models. These findings suggest its potential utility in metabolic research, particularly concerning obesity and diabetes. Nonetheless, further studies are required to fully understand its mechanisms of action and to explore its applicability in clinical settings.

Reference:

Lin, H. Y., Yang, S. H., Tang, H. Y., Cheng, G. Y., Davis, P. J., & Grasso, P. (2014). Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K. Peptides, 57, 95-100.