[Leu5]-Enkephalin

Product Name:[Leu5]-Enkephalin

Synonyms:Leu-enkephalin

CAS No:58822-25-6

Purity:95%

Molar Mass:555.6

Chemical Formula:C28H37N5O7

Storage:Store at -20 degrees Celsius

Sequence:YGGFL

Application:[Leu5]-Enkephalin is an endogenous opioid peptide that plays a crucial role in modulating pain, mood, and various neurophysiological processes. This pentapeptide binds to delta-opioid receptors in the central nervous system, where it inhibits neurotransmitter release and reduces the perception of pain. [Leu5]-Enkephalin is particularly valuable in research focused on understanding the mechanisms of opioid receptor activation, analgesia, and the body's natural pain management systems. With its high purity and biological relevance, [Leu5]-Enkephalin is an essential tool for studies in neuropharmacology, pain research, and the development of novel analgesics.

Current Research:

[Leu5]-Enkephalin, also known as leucine enkephalin, is an endogenous pentapeptide with the amino acid sequence Tyr-Gly-Gly-Phe-Leu. It functions as a neurotransmitter and neuromodulator, primarily interacting with opioid receptors in the central nervous system.
Receptor Affinity and Function
Leucine enkephalin exhibits agonistic activity at both ??-opioid (MOR) and ??-opioid receptors (DOR), with a higher affinity for DOR. Upon binding to these receptors, it modulates pain perception and induces analgesia. Additionally, it influences various physiological processes, including mood regulation and stress responses.
Physiological Role
As a member of the enkephalin family, leucine enkephalin plays a crucial role in the body's endogenous pain control system. It is widely distributed in the brain and spinal cord, where it inhibits the release of neurotransmitters involved in pain transmission, thereby diminishing pain signals.
Clinical Implications
Understanding the function of leucine enkephalin has significant implications for pain management and the development of analgesic drugs. By targeting the pathways modulated by this peptide, novel therapeutic strategies can be devised to treat pain and related disorders.
In summary, [Leu^5]-Enkephalin is a pivotal component of the endogenous opioid system, contributing to pain modulation and various neurophysiological processes. Its interactions with opioid receptors underscore its potential as a target for therapeutic interventions in pain management.

Reference:

Do, T. D., LaPointe, N. E., Sangwan, S., Teplow, D. B., Feinstein, S. C., Sawaya, M. R., ... & Bowers, M. T. (2014). Factors that drive peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants. The Journal of Physical Chemistry B, 118(26), 7247-7256.