[Lys(Ac)12/16, Lys(Me3)20]-Histone H4 (1-25)-GSGSK(Biotin)

Product Name: [Lys(Ac)12/16, Lys(Me3)20]-Histone H4 (1-25)-GSGSK(Biotin)

Sequence One Letter Code: SGRGKGGKGLG-K(Ac)-GGA-K(Ac)-RHR-K(Me3)-VLRDN-GSGSK(Biotin)

Sequence Three Letter Code: H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys(Ac)-Gly-Gly-Ala-Lys(Ac)-Arg-His-Arg-Lys(Me3)-Val-Leu-Arg-Asp-Asn-Gly-Ser-Gly-Ser-Lys(Biotin)-OH

Molecular Weight: 3360

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: Histone H4 (1–25), K12ac/K16ac/K20me3-Biotin is a synthetic histone H4 peptide carrying acetylation at lysines 12 and 16 together with trimethylation at lysine 20. H4K20 trimethylation, catalyzed by Suv4-20, is associated with transcriptional silencing and heterochromatin formation, while H4K12 and H4K16 acetylation modulate chromatin accessibility and protein recruitment. This combinatorial modification pattern provides a useful model for studying complex histone crosstalk. The C-terminal GSGSK linker and biotinylated lysine support affinity capture, pull-down assays, and chromatin-associated protein interaction studies.