[Lys(Ac)12]-Histone H4 (1-25)-GSGSK(Biotin)

Product Name: [Lys(Ac)12]-Histone H4 (1-25)-GSGSK(Biotin)

Sequence One Letter Code: SGRGKGGKGLG-K(Ac)-GGAKRHRKVLRDN-GSGSK(Biotin)

Sequence Three Letter Code: H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys(Ac)-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val-Leu-Arg-Asp-Asn-Gly-Ser-Gly-Ser-Lys(Biotin)-OH

Molecular Weight: 3274.9

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: Histone H4 (1–25), K12ac-Biotin is a synthetic histone H4 peptide acetylated at lysine 12, an epigenetic modification involved in chromatin organization and heterochromatin formation. H4K12 acetylation has been linked to subsequent methylation of histone H3 lysine 9, connecting histone acetylation with repressive chromatin-state regulation. The peptide contains a C-terminal GSGSK linker followed by biotinylated lysine, enabling affinity purification, pull-down, and binding studies. This acetylated histone peptide is commonly used in epigenetics research to examine histone modification interplay, chromatin-associated protein recruitment, transcriptional regulation, and acetylation-dependent binding mechanisms.