[Lys(Me2)27]-Histone H3 (21-44)-GK(Biotin)

Product Name: [Lys(Me2)27]-Histone H3 (21-44)-GK(Biotin)

Sequence One Letter Code: ATKAAR-K(Me2)-SAPATGGVKKPHRYRPG-GK(Biotin)

Sequence Three Letter Code: H-Ala-Thr-Lys-Ala-Ala-Arg-Lys(Me2)-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-Gly-Lys(Biotin)-OH

Molecular Weight: 2945.6

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: [Lys(Me2)27]-Histone H3 (21–44)-GK(Biotin) is a synthetic histone H3 peptide corresponding to residues 21–44 and carrying dimethylation at lysine 27. H3K27me2 is an epigenetic mark closely associated with transcriptional repression, facultative heterochromatin formation, and gene-silencing mechanisms. The peptide contains a C-terminal glycine and biotinylated lysine, making it suitable for affinity capture, interaction profiling, and enzymatic assay applications. This modified histone peptide is commonly used to study Polycomb-related pathways, histone methyltransferase activity, demethylase function, chromatin-associated protein complexes, and the molecular mechanisms regulating epigenetic gene expression.