[Lys(Me3)79]-Histone H3(73-83)

Product Name: [Lys(Me3)79]-Histone H3(73-83)

Sequence One Letter Code: EIAQDF-K(Me3)-TDLR

Sequence Three Letter Code: H-Glu-Ile-Ala-Gln-Asp-Phe-Lys(Me3)-Thr-Asp-Leu-Arg-OH

Molecular Weight: 1378.6

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Unconjugated

 Code Nacres: NA.26

Application: [Lys(Me3)79]-Histone H3 (73–83) is a synthetic histone H3 peptide spanning residues 73–83 and featuring trimethylation at lysine 79. H3K79 methylation is an important epigenetic modification involved in transcriptional regulation, DNA damage response, and chromatin organization. Unlike many histone marks located on the N-terminal tail, H3K79 methylation occurs within the histone core region and is catalyzed by Dot1/DOT1L methyltransferase. This peptide is widely used to study Dot1L activity, methyl-lysine recognition, epigenetic gene regulation, chromatin-associated signaling, and disease-related mechanisms involving H3K79 methylation.