MCL 0020

Product Name: MCL 0020

CAS No: 475498-26-1

Purity: 95%

Molar Mass: 609.7

Chemical Formula: C34H39N7O4

Storage: Store at -20 degrees Celsius

Sequence: XRX

Target: melanocortin MC4

Application:

MCL 0020 is a synthetic peptide designed to modulate the activity of the melanocortin receptors, particularly MC4R. It acts as an agonist, binding to these receptors to influence energy homeostasis, appetite control, and sexual function. MCL 0020 is widely used in research focused on understanding metabolic disorders such as obesity and type 2 diabetes, as well as in the study of sexual dysfunction. Its ability to interact with the central nervous system and regulate physiological responses makes it a valuable tool in developing therapeutic strategies for metabolic and endocrine diseases.

Current Research:

MCL 0020 is a potent and selective antagonist of the melanocortin-4 receptor (MC4R), a G-protein-coupled receptor involved in regulating energy homeostasis, feeding behavior, and stress responses. With an inhibitory concentration (IC??) of 11.63 nM for MC4R, MCL 0020 exhibits significantly lower affinity for other melanocortin receptors, such as MC3R (IC?? = 1,115 nM) and MC1R (IC?? > 10,000 nM), underscoring its selectivity. In behavioral studies, administration of MCL 0020 has been shown to dose-dependently attenuate restraint stress-induced anorexia in rodent models without affecting baseline food intake in free-feeding conditions. This suggests that MC4R plays a critical role in mediating stress-related feeding behaviors, and that MCL 0020 can modulate these effects. Additionally, MCL 0020 has demonstrated anxiolytic-like activity in vivo. In light/dark exploration tests, a common assay for assessing anxiety-related behavior in rodents, MCL 0020 reduced swim stress-induced anxiogenic-like responses, indicating its potential utility in modulating stress and anxiety through MC4R pathways. The specificity and efficacy of MCL 0020 in targeting MC4R make it a valuable tool for dissecting the physiological and pathological roles of this receptor. Its applications extend to exploring therapeutic strategies for conditions such as stress-induced anorexia, anxiety disorders, and other pathologies where MC4R signaling is implicated. In summary, MCL 0020 serves as a significant molecular agent in the study of MC4R functions, offering insights into the receptor's involvement in stress and feeding behaviors. Ongoing research continues to elucidate its potential in developing targeted treatments for related disorders.

Reference: Bednarek, M. A., & Fong, T. M. (2004). Ligands of the melanocortin receptors, 2002-2003 update. Expert Opinion on Therapeutic Patents, 14(3), 327-336.